Artificial gravity with ergometric exercise as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans
Artificial gravity with ergometric exercise as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans
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在人类头低位卧床休息 4 天期间，人工重力和测力运动可作为对抗心血管失调的对策
DOI：
10.1007/s00421-011-1866-7
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发表时间：
2011
影响因子：
3
通讯作者：
Xi
中科院分区：
文献类型：
--
作者：
Yong;Chang;Yan;Yuan Gao;Dongyuan Lu;F. Shi;Xiaole Wei;Xi
我们之前已经证明，短臂离心机和有氧运动训练相结合可以保留人类几种重要的生理心血管功能。我们假设人工重力（AG）和运动可以有效预防头向下卧床（HDBR）期间身体问题的变化。为了验证这一假设，12名健康男性受试者接受了4天的6°HDBR。其中6只小鼠每天2次，在足部水平上以+1.0和+2.0 Gz的2分钟间隔交替暴露30分钟，卧床休息期间进行40 W的人体运动作为对策（CM组），其余6只小鼠作为未经治疗的对照组（无CM组）。卧床休息前后4天，通过静脉闭塞容积描记术评估腿部静脉血流动力学，通过血压和心率功率谱分析评估自主心血管控制。此外，通过75°平头倾斜测试评估直立耐受性，通过卧床休息前后的近最大体力工作能力测试调查体力工作能力。数据显示，在4天的HDBR中，每天两次，共60分钟的离心和运动联合使用可以防止(a)工作能力下降，(b)自主神经功能障碍（心脏副交感神经活动减少）和(c)腿部静脉流动阻力增加。每天2次+1.0和+2.0 Gz交替30分钟，结合40 W的人体运动，可能是一种有希望的短时间模拟微重力的对策。
We have shown previously that combined short-arm centrifuge and aerobic exercise training preserved several physiologically important cardiovascular functions in humans. We hypothesized that artificial gravity (AG) and exercise is effective to prevent changes of physical problems during head-down bed rest (HDBR). To test this hypothesis, 12 healthy male subjects had undergone 4 days of 6° HDBR. Six of them were exposed to AG of an alternating 2-min intervals of +1.0 and +2.0 Gz at foot level for 30 min twice per day with ergometric exercise of 40 W as a countermeasure during bed rest (CM group), while the remaining six served as untreated controls (no-CM group). Before and after 4 days of bed rest, leg venous hemodynamics was assessed by venous occlusion plethysmography and autonomic cardiovascular control estimated by power spectral analysis of blood pressure and heart rate. Further, orthostatic tolerance was evaluated by a 75° head-up tilt test and physical working capacity was surveyed by near maximal physical working capacity test before and after bed rest. The data showed that combined centrifuge and exercise applied twice daily for a total of 60 min during 4 days of HDBR prevented (a) a decrease in working capacity, (b) autonomic dysfunction (a decrease in the activity of parasympathetic cardiac innervation) and (c) an increase in leg venous flow resistance. The combination of a 30 min alternating of +1.0 and +2.0 Gz for twice per day of AG with 40 W ergometric exercise may offer a promising countermeasure to short duration simulated microgravity.
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影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
3.3
作者：
William H. Cooke;J. E. Ames;Alexandra A. Crossman;J. Cox;Tom A. Kuusela;Kari U. O. Tahvanainen;L. Boyce Moon;Jürgen Drescher;F. Baisch;Tadaaki Mano;Benjamin D. Levine;C. Blomqvist;D. Eckberg
通讯作者：
William H. Cooke;J. E. Ames;Alexandra A. Crossman;J. Cox;Tom A. Kuusela;Kari U. O. Tahvanainen;L. Boyce Moon;Jürgen Drescher;F. Baisch;Tadaaki Mano;Benjamin D. Levine;C. Blomqvist;D. Eckberg
影响因子：
3.3
作者：
FRITSCHYELLE, JM;CHARLES, JB;ECKBERG, DL
通讯作者：
ECKBERG, DL
卧床休息 18 天对腿部和手臂静脉特性的影响。
DOI：
10.1152/japplphysiol.00835.2003
发表时间：
2004
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Bleeker,MWP;DeGroot,PCE;Pawelczyk,JA;Hopman,MTE;Levine,BD
通讯作者：
Levine,BD
DOI：
10.1152/ajpheart.2001.280.5.h2230
发表时间：
2001
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Pawelczyk,JA;Zuckerman,JH;Blomqvist,CG;Levine,BD
通讯作者：
Levine,BD