Dominance status predicts social fear transmission in laboratory rats.

Dominance status predicts social fear transmission in laboratory rats.
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DOI:
10.1007/s10071-016-1013-2
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发表时间:
2016-11
期刊:
影响因子:
2.7
通讯作者:
Monfils, Marie-H.
Monfils, Marie-H.
中科院分区:
生物学2区
文献类型:
--
作者:
Jones, Carolyn E.;Monfils, Marie-H.

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通过直接经验或从社会背景中推断,获取有关预测危险的刺激的信息,对于个体产生适当行为以应对威胁的能力至关重要。利用修改后的示范者-观察者范式(恐惧条件反射的代理),允许受试者之间的自由互动,我们表明,社会优势等级,和笼中大鼠的互动社会行为,是预测的社会恐惧传输,与下属大鼠表现出增加的恐惧反应后,与恐惧条件反射的优势大鼠在恐惧检索。代理恐惧条件反射保留了直接恐惧学习所必需的一些途径(例如,外侧杏仁核)但其独特之处在于其需要情绪调节所必需的区域(例如,前扣带皮层),使这一范式的一个重要工具,在实验室环境中评估学习和行为。本文的在线版本(doi:10.1007/s10071-016-1013-2)包含补充材料,可供授权用户使用。
Acquiring information about stimuli that predict danger, through either direct experience or inference from a social context, is crucial for individuals’ ability to generate appropriate behaviors in response to threats. Utilizing a modified demonstrator–observer paradigm (fear conditioning by proxy) that allows for free interaction between subjects, we show that social dominance hierarchy, and the interactive social behaviors of caged rats, is predictive of social fear transmission, with subordinate rats displaying increased fear responses after interacting with a fear-conditioned dominant rat during fear retrieval. Fear conditioning by proxy conserves some of the pathways necessary for direct fear learning (e.g., lateral amygdala) but is unique in that it requires regions necessary for emotional regulation (e.g., anterior cingulate cortex), making this paradigm an important tool for evaluating learning and behavior in the laboratory setting. The online version of this article (doi:10.1007/s10071-016-1013-2) contains supplementary material, which is available to authorized users.
DOI: 10.1371/journal.pone.0021855
发表时间: 2011
期刊: PloS one
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