Functional Amyloid and Other Protein Fibers in the Biofilm Matrix.

Functional Amyloid and Other Protein Fibers in the Biofilm Matrix.
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DOI:
10.1016/j.jmb.2018.07.026
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发表时间:
2018-10-12
影响因子:
5.6
通讯作者:
Stanley-Wall NR
Stanley-Wall NR
中科院分区:
生物学2区
文献类型:
--
作者:
Erskine E;MacPhee CE;Stanley-Wall NR

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Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria. Biofilms are complex communities of bacteria encased in an extracellular matrix. The biofilm matrix frequently contains fibrous proteins. Many of the proteins have been designated amyloid-like fibers. We review the designation in light of biochemical and biophysical data.
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