BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots.
BAM1/2 receptor kinase signaling drives CLE peptide-mediated formative cell divisions in Arabidopsis roots.
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BAM1/2受体激酶信号驱动CLE多肽介导的拟南芥根形成细胞分裂。
DOI：
10.1073/pnas.2018565117
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发表时间：
2020-12-22
影响因子：
11.1
通讯作者：
Nimchuk ZL
中科院分区：
文献类型：
--
作者：
Crook AD;Willoughby AC;Hazak O;Okuda S;VanDerMolen KR;Soyars CL;Cattaneo P;Clark NM;Sozzani R;Hothorn M;Hardtke CS;Nimchuk ZL
植物体内计划的适当制定需要在复杂组织的发育过程中协调细胞分裂模式。细胞周期机制的激活对这一过程至关重要，但目前尚不清楚这一过程如何或是否与在发育过程中至关重要的细胞间通讯网络相联系。在这里，我们证明了产生植物根的关键细胞分裂是由细胞间的信号肽控制的，这些信号肽通过植物特有的受体激酶来控制特定的细胞周期调控基因的表达。我们发现，细胞周期蛋白D基因的表达依赖于受体信号和短根转录因子，以确保及时和稳健的细胞分裂模式。细胞分裂通常由细胞外信号网络调节，以确保发育过程中正确的模式。在拟南芥中，短根(SHR)/稻草人(SCR)转录因子二聚体激活CyCLIND6；1(CyCD6；1)，以推动根基组织发育过程中的形成分裂。在这里，我们展示了质膜定位，几乎没有任何MERISTEM1/2(BAM1/2)家族受体激酶是SHR依赖的形成分裂和CyCD6；1表达所必需的，但不是SHR依赖的基础组织规范。富含根的CLE配体结合BAM1胞外区，是激活SHR介导的分裂和CyCD6；1表达的必要条件和充分条件。相应地，BAM-CLE信号有助于限制远端根区域的形成分裂。此外，遗传分析表明，BAM-CLE和SHR会聚在一起，调节基础组织外的额外细胞分裂。我们的工作确定了调控形成根分裂的细胞外信号途径，并提供了一个在模式形成和进化中探索这一途径的框架。
Proper elaboration of the plant body plan requires that cell division patterns are coordinated during development in complex tissues. Activation of cell cycle machinery is critical for this process, but it is not clear how or if this links to cell-to-cell communication networks that are important during development. Here we show that key cell divisions that generate the plant root are controlled by cell-to-cell signaling peptides which act through plant-specific receptor kinases to control expression of a specific cyclinD cell cycle regulatory gene. We show that cyclinD gene expression depends on both receptor signaling and the SHORT-ROOT transcription factor to ensure timely and robust cell division patterns. Cell division is often regulated by extracellular signaling networks to ensure correct patterning during development. In Arabidopsis, the SHORT-ROOT (SHR)/SCARECROW (SCR) transcription factor dimer activates CYCLIND6;1 (CYCD6;1) to drive formative divisions during root ground tissue development. Here, we show plasma-membrane-localized BARELY ANY MERISTEM1/2 (BAM1/2) family receptor kinases are required for SHR-dependent formative divisions and CYCD6;1 expression, but not SHR-dependent ground tissue specification. Root-enriched CLE ligands bind the BAM1 extracellular domain and are necessary and sufficient to activate SHR-mediated divisions and CYCD6;1 expression. Correspondingly, BAM-CLE signaling contributes to the restriction of formative divisions to the distal root region. Additionally, genetic analysis reveals that BAM-CLE and SHR converge to regulate additional cell divisions outside of the ground tissues. Our work identifies an extracellular signaling pathway regulating formative root divisions and provides a framework to explore this pathway in patterning and evolution.
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影响因子：
3.7
作者：
Gregory EF;Dao TQ;Alexander MA;Miller MJ;Fletcher JC
通讯作者：
Fletcher JC
DOI：
10.1242/dev.127613
发表时间：
2015-12-01
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Kurihara D;Mizuta Y;Sato Y;Higashiyama T
通讯作者：
Higashiyama T
影响因子：
64.5
作者：
Cruz-Ramírez A;Díaz-Triviño S;Blilou I;Grieneisen VA;Sozzani R;Zamioudis C;Miskolczi P;Nieuwland J;Benjamins R;Dhonukshe P;Caballero-Pérez J;Horvath B;Long Y;Mähönen AP;Zhang H;Xu J;Murray JA;Benfey PN;Bako L;Marée AF;Scheres B
通讯作者：
Scheres B
影响因子：
9.8
作者：
Levesque MP;Vernoux T;Busch W;Cui H;Wang JY;Blilou I;Hassan H;Nakajima K;Matsumoto N;Lohmann JU;Scheres B;Benfey PN
通讯作者：
Benfey PN
影响因子：
56.9
作者：
Kondo, Tatsuhiko;Sawa, Shinichiro;Sakagami, Youji
通讯作者：
Sakagami, Youji