Bovine Spongiform Encephalopathy: A Neuropathological Perspective
Bovine Spongiform Encephalopathy: A Neuropathological Perspective
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牛海绵状脑病：神经病理学视角
DOI：
10.1111/j.1750-3639.1991.tb00642.x
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发表时间：
1991
期刊：
影响因子：
6.4
通讯作者：
I. McGill
中科院分区：
文献类型：
--
作者：
G. Wells;J. Wilesmith;I. McGill
牛海绵状脑病（BSE）的发生，认识到这是一种新的羊瘙痒病样疾病在英国的家畜中流行，并关注远程人畜共患病的可能性，在四年内，产生了大量的记录信息。虽然其中大部分信息已经通过科学文献进行了交流，但本文试图从神经病理学的角度总结出现的主要发现。最初的研究确定了疯牛病与动物和人类的亚急性海绵状脑病或“朊病毒”疾病的疾病学同源性。流行病学数据与一种扩展的共同源流行病一致，该流行病起源于1981 - 82年开始的一次突变，即家畜暴露于商业动物饲料中的肉骨粉中的一种羊瘙痒病样因子。目前认为，肉骨粉的生产方法是导致暴露量变化的重要因素。空泡病变在自然发病和初次传播给牛时的分布模式不变，表明BSE的发病机制是一致的。对小鼠的研究表明，不同的疯牛病分离株的生物学特性也是一致的，但表明这些特性与羊瘙痒病分离株的特性不同。虽然人类健康风险被认为微不足道，但已通过各种战略加以解决，包括法定措施和长期监测。
The occurrence of bovine spongiform encephalopathy (BSE), recognition that it is a new scrapie‐like disease epidemic in domestic cattle in the United Kingdom and concern of a remote zoonotic potential has, in four years, produced a plethora of documented information. While much of this information has been communicated outwith the scientific literature, this review attempts to summarise, from a neuropathological viewpoint, the main findings to emerge. The initial studies established the nosological homology of BSE with the subacute spongiform encephalopathies or “prion” diseases of animals and man. Epidemiological data are consistent with an extended common source epidemic originating from an abrupt change, commencing in 1981‐82, in the exposure of domestic cattle to a scrapie‐like agent in meat and bone meal incorporated into commercial animal feedstuffs. It is currently proposed that the method of production of meat and bone meal has contributed vital factors to the change in exposure. Invariability of the distribution pattern of vacuolar pathology in the natural disease and on primary transmission to cattle suggests a uniformity of the pathogenesis of BSE. Studies in mice suggest uniformity also of the biological properties of different BSE isolates but indicate that the properties differ from those of sheep scrapie isolates. Human health risks, although perceived to be negligible, have been addressed by various strategies including statutory measures and long term monitoring.
来自非常规慢病毒疾病的感染特异性颗粒。
DOI：
10.1126/science.6377496
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Merz,PA;Rohwer,RG;Kascsak,R;Wisniewski,HM;Somerville,RA;GibbsJr,CJ;Gajdusek,DC
通讯作者：
Gajdusek,DC
检测受瘙痒病影响的绵羊的瘙痒病相关原纤维 (SAF) 和 SAF 蛋白。
DOI：
10.1093/infdis/156.1.36
发表时间：
1987
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Rubenstein,R;Merz,PA;Kascsak,RJ;Carp,RI;Scalici,CL;Fama,CL;Wisniewski,HM
通讯作者：
Wisniewski,HM