The Use of Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity.
The Use of Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity.
复制标题
DOI：
10.3389/fpubh.2018.00153
复制
发表时间：
2018
影响因子：
5.2
通讯作者：
Brown S
中科院分区：
文献类型：
--
作者：
Blackwell LF;Cooke DG;Brown S
女性正常卵巢活动的模式可以从童年到更年期采取多种形式。这些模式处于从无卵巢活动到完全可育的排卵周期的连续体上，但在其他定义的模式中，有无排卵卵巢活动的周期，包括黄体化未破裂卵泡（LUF）和黄体期不足或短的排卵周期。对于任何女性来说，这些模式可以以任何顺序发生，一个可以合并到下一个，而不会发生出血，或者完全被忽略。因此，目前尚不可能预测未来周期的模式，但可以利用我们对连续体的了解来解释当前周期，这对个人生育率的管理具有明确的影响。通过每天监测卵巢激素排泄率，可以直接在真实的时间内监测个体在连续体中的位置，而无需进行统计型计算或参考群体平均值和标准偏差。尿雌酮葡萄糖醛酸苷（E1G）的排泄可直接测量卵泡生长，排卵后E1G峰值后尿孕激素葡萄糖醛酸苷（PdG）的升高可提供排卵的良好证据。PdG排泄率的特定值可用于确定周期是否无排卵伴或不伴LUF，或排卵和不育或排卵和生育。这些具体的价值观是在连续体中导航的重要路标。妇女要利用这一连续体的知识，数据必须可靠，对数据的解释必须以科学为基础，并以适当的形式提供。我们讨论了获取和提供这些信息的各种因素，使每个妇女能够驾驭自己的生殖生活。
The patterns of a woman's normal ovarian activity can take many forms from childhood to menopause. These patterns lie on a continuum ranging from no ovarian activity to a fully fertile ovulatory cycle, but among the other defined patterns are cycles with anovulatory ovarian activity, including luteinized unruptured follicles (LUFs), and ovulatory cycles with deficient or short luteal phases. For any woman, these patterns can occur in any order, and one can merge into the next, without an intervening bleed, or be missed entirely. Consequently, it is not yet possible to predict the pattern of a future cycle, but it is possible to use our knowledge of the continuum to interpret the current cycle, which has clear implications for the management of personal fertility. An individual's position in the continuum can be monitored directly in real time by daily monitoring of ovarian hormone excretion rates, without either calendar-type calculations or reference to population means and standard deviations. The excretion of urinary estrone glucuronide (E1G) gives a direct measure of follicular growth, and the post-ovulatory rise in urinary pregnanediol glucuronide (PdG) following an E1G peak provides good evidence of ovulation. Specific values of the PdG excretion rate can be used to determine whether a cycle is anovulatory with or without a LUF, or is ovulatory and infertile or ovulatory and fertile. These specific values are important signposts for navigating the continuum. For a woman to take advantage of the knowledge of the continuum, the data must be reliable, and their interpretation has to be based on the underlying science and provided in an appropriate form. We discuss the various factors involved in acquiring and providing such information to enable each woman to navigate her own reproductive life.
登录
查看更多内容
影响因子：
2.9
作者：
Allaway, Heather C. M.;Williams, Nancy I.;De Souza, Mary Jane
通讯作者：
De Souza, Mary Jane
影响因子：
--
作者：
Binnie, Jan E;Cooke, Delwyn G;Blackwell, Leonard F
通讯作者：
Blackwell, Leonard F
DOI：
10.1016/s0002-9378(11)90568-7
发表时间：
1991-12-01
影响因子：
9.8
作者：
BROWN, JB;HOLMES, J;BARKER, G
通讯作者：
BARKER, G
影响因子：
4
作者：
BROWN, JB;MACLEOD, SC;SMYTH, B
通讯作者：
SMYTH, B
影响因子：
2.7
作者：
BLACKWELL, LF;BROWN, JB
通讯作者：
BROWN, JB