Cognitive impairment and the regional distribution of cerebellar lesions in multiple sclerosis.
Cognitive impairment and the regional distribution of cerebellar lesions in multiple sclerosis.
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DOI：
10.1177/1352458517730132
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Klawiter EC
中科院分区：
文献类型：
--
作者：
Tobyne SM;Ochoa WB;Bireley JD;Smith VM;Geurts JJ;Schmahmann JD;Klawiter EC
复发缓解型MS（RRMS）中经常报告小脑病变，并与运动功能和认知状态受损相关。然而，先前的研究主要集中在小脑受累的概括性测量（例如，总病变负荷，灰/白色物质体积），而不是小脑白色物质特定区域内病变负荷的影响。在空间上绘制RRMS中小脑白色病变发生的概率，并探索认知障碍与小脑内病变（CWML）位置之间的关系。在3 T条件下，对16名认知功能受损（CI）和15名认知功能保留（CP）的RRMS受试者进行高分辨率结构MRI检查，并用于病变识别和体素病变症状分析（VLSM）。CI RRMS表现为小脑中脚（MCP）的好发性。VLSM结果表明，MCP的病变与RRMS中的CI显著相关。小脑损伤负荷的测量值与疾病发作时的年龄相关，但与疾病持续时间无关。涉及MCP的小脑病变的特定模式，而不是总小脑白色病变负荷，有助于RRMS的认知功能障碍。小脑病变特征可以提供RRMS认知状态改变的当前或演变风险的生物标志物。
Cerebellar lesions are often reported in relapsing remitting MS (RRMS), and have been associated with impaired motor function and cognitive status. However, prior research has primarily focused on summary measures of cerebellar involvement (e.g. total lesion load, gray/white matter volume) and not on the effect of lesion load within specific regions of cerebellar white matter. Spatially map the probability of cerebellar white matter lesion occurrence in RRMS and explore the relationship between cognitive impairment and lesion (CWML) location within the cerebellum. High resolution structural MRI was acquired on 16 cognitively impaired (CI) and 15 cognitively preserved (CP) RRMS subjects at 3T and used for lesion identification and voxel-lesion symptom analysis (VLSM). CI RRMS demonstrated a predilection for the middle cerebellar peduncle (MCP). VLSM results indicate that lesions of the MCP are significantly associated with CI in RRMS. Measures of cerebellar lesion load were correlated with age at disease onset but not disease duration. A specific pattern of cerebellar lesions involving the MCP, rather than the total cerebellar white matter lesion load, contributes to cognitive dysfunction in RRMS. Cerebellar lesion profiles may provide a biomarker of current or evolving risk for cognitive status change in RRMS.
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影响因子：
3.3
作者：
Keil, Boris;Blau, James N.;Biber, Stephan;Hoecht, Philipp;Tountcheva, Veneta;Setsompop, Kawin;Triantafyllou, Christina;Wald, Lawrence L.
通讯作者：
Wald, Lawrence L.
影响因子：
14.5
作者：
Schmahmann, JD;Sherman, JC
通讯作者：
Sherman, JC
影响因子：
3.3
作者：
Amato, Maria Pia;Portaccio, E.;Razzolini, L.
通讯作者：
Razzolini, L.
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
5.7
作者：
Diedrichsen, Jorn
通讯作者：
Diedrichsen, Jorn