Longitudinal association of C-reactive protein and lung function over 13 years: The EPIC-Norfolk study.
Longitudinal association of C-reactive protein and lung function over 13 years: The EPIC-Norfolk study.
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DOI：
10.1093/aje/kwt208
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发表时间：
2014-01-01
影响因子：
5
通讯作者：
Khaw KT
中科院分区：
文献类型：
--
作者：
Ahmadi-Abhari S;Kaptoge S;Luben RN;Wareham NJ;Khaw KT
已知慢性阻塞性肺疾病与全身炎症有关。我们对来自诺福克欧洲癌症前瞻性研究的18,110名男性和女性进行了C反应蛋白（CRP）和肺功能的纵向相关性研究，这些男性和女性在基线时（1993-1997年招募）年龄为40-79岁，随访至2011年。我们通过测量基线、4年和13年时的用力肺活量（FVC）和1秒用力呼气量（FEV 1）来评估肺功能。在基线和13年随访时使用高灵敏度测定法测量血清CRP水平。使用多变量线性混合模型检查loge-CRP和肺功能的横截面和纵向相关性。在横断面分析中，基线loge-CRP增加1个标准差（CRP在原始mg/L标度上增加约3倍）与FEV 1减少−86.3 mL（95%置信区间：−93.9，−78.6）相关。在纵向分析中，13年内loge-CRP增加1个标准差也与同期FEV 1下降-64.0 mL（95%置信区间：-72.1，-55.8）相关。FVC的相关性相似，并且在终生不吸烟者中持续存在。基线CRP水平不能预测FEV 1或FVC随时间的变化率。在本研究中，我们发现了纵向观察证据，表明全身炎症的增加与肺功能的下降有关。
Chronic obstructive pulmonary disease is known to be associated with systemic inflammation. We examined the longitudinal association of C-reactive protein (CRP) and lung function in a cohort of 18,110 men and women from the European Prospective Investigation Into Cancer in Norfolk who were 40–79 years of age at baseline (recruited in 1993–1997) and followed-up through 2011. We assessed lung function by measuring forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) at baseline, 4 years, and 13 years. Serum CRP levels were measured using a high-sensitivity assay at baseline and the 13-year follow up. Cross-sectional and longitudinal associations of loge-CRP and lung function were examined using multivariable linear mixed models. In the cross-sectional analysis, 1-standard-deviation increase in baseline loge-CRP (about 3-fold higher CRP on the original milligrams per liter scale) was associated with a −86.3 mL (95% confidence interval: −93.9, −78.6) reduction in FEV1. In longitudinal analysis, a 1-standard-deviation increase in loge-CRP over 13 years was also associated with a −64.0 mL (95% confidence interval: −72.1, −55.8) decline in FEV1 over the same period. The associations were similar for FVC and persisted among lifetime never-smokers. Baseline CRP levels were not predictive of the rate of change in FEV1 or FVC over time. In the present study, we found longitudinal observational evidence that suggested that increases in systemic inflammation are associated with declines in lung function.
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DOI：
10.1164/ajrccm.164.8.2008109
发表时间：
2001-10-15
影响因子：
24.7
作者：
Eid, AA;Ionescu, AA;Shale, DJ
通讯作者：
Shale, DJ
DOI：
10.1080/15287390903248901
发表时间：
2010-01-01
影响因子：
2.6
作者：
Sawyer, K.;Mundandhara, S.;Madden, M. C.
通讯作者：
Madden, M. C.
影响因子：
5
作者：
Jiang, Rui;Burke, Gregory L.;Barr, R. Graham
通讯作者：
Barr, R. Graham
DOI：
10.1165/ajrcmb.19.1.3132
发表时间：
1998-07-01
影响因子：
6.4
作者：
Quay, JL;Reed, W;Devlin, RB
通讯作者：
Devlin, RB
影响因子：
3.5
作者：
De Martinis, M;Franceschi, C;Ginaldi, L
通讯作者：
Ginaldi, L