mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch.
mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch.
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DOI：
10.1371/journal.pone.0037807
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Maenhaut C
中科院分区：
文献类型：
--
作者：
Hébrant A;Dom G;Dewaele M;Andry G;Trésallet C;Leteurtre E;Dumont JE;Maenhaut C
间变性甲状腺癌（ATC）是甲状腺肿瘤中最致命的一种，是甲状腺肿瘤进展的终末期。目前还没有有效的治疗方法。ATC常起源于预后良好的甲状腺乳头状癌（PTC）。在这项研究中，我们分析了59甲状腺肿瘤（11 ATC和48 PTC）的mRNA表达谱的微阵列。ATC和PTC显示出很大程度上重叠的mRNA表达谱，在所有ATC中调节的大多数基因也在几个PTC中调节。在所有PTC中调节的探针中，有43%在所有ATC中受到类似的调节。在PTC中观察到的许多基因调节在ATC中被放大。这说明ATC主要来源于PTC。由9个基因组成的侵袭性分子特征清楚地区分了这两种肿瘤。此外，本研究还证实了与ATC或PTC表型相对应的基因调控，如炎症反应、上皮细胞向间质细胞转化（EMT）和侵袭、高增殖率、去分化、钙化和纤维化过程、高糖代谢和糖酵解、乳酸产生和化学抗性。两种肿瘤类型之间的主要质的差异在于ATC显示的更强的EMT、去分化和糖酵解表型。
Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid neoplasia and represents the end stage of thyroid tumor progression. No effective treatment exists so far. ATC frequently derive from papillary thyroid carcinomas (PTC), which have a good prognosis. In this study, we analyzed the mRNA expression profiles of 59 thyroid tumors (11 ATC and 48 PTC) by microarrays. ATC and PTC showed largely overlapping mRNA expression profiles with most genes regulated in all ATC being also regulated in several PTC. 43% of the probes regulated in all the PTC are similarly regulated in all ATC. Many genes modulations observed in PTC are amplified in ATC. This illustrates the fact that ATC mostly derived from PTC. A molecular signature of aggressiveness composed of 9 genes clearly separates the two tumors. Moreover, this study demonstrates gene regulations corresponding to the ATC or PTC phenotypes like inflammatory reaction, epithelial to mesenchymal transition (EMT) and invasion, high proliferation rate, dedifferentiation, calcification and fibrosis processes, high glucose metabolism and glycolysis, lactate generation and chemoresistance. The main qualitative differences between the two tumor types bear on the much stronger EMT, dedifferentiation and glycolytic phenotypes showed by the ATC.
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影响因子：
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影响因子：
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作者：
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