Efficacy of therapeutic soft contact lens in the management of gelatinous drop-like corneal dystrophy
Efficacy of therapeutic soft contact lens in the management of gelatinous drop-like corneal dystrophy
复制标题
治疗性软性隐形眼镜治疗凝胶状水滴样角膜营养不良的疗效
DOI：
10.1136/bjophthalmol-2018-313809
复制
发表时间：
2019
影响因子：
4.1
通讯作者：
Nishida Kohji
中科院分区：
文献类型：
--
作者：
Maeno Sayo;Soma Takeshi;Tsujikawa Motokazu;Shigeta Ryujiro;Kawasaki Ryo;Oie Yoshinori;Koh Shizuka;Maruyama Kazuichi;Kawasaki Satoshi;Maeda Naoyuki;Nishida Kohji
背景/AimsTo探讨治疗性软性角膜接触镜（SCL）在凝胶状滴状角膜营养不良（GDLD）management.MethodsThis的疗效是一个回顾性的，连续的，观察性病例系列，包括20例（40只眼）GDLD在大坂大学医院治疗在过去的15年。我们测试了治疗性SCL对临床特征、视力和手术干预的影响。对3年未行手术治疗的患者进行临床特征和视力检查。使用Fisher精确检验和Mann-Whitney U检验对三个主要临床GDLD特征和视力（logMAR单位）的变化进行评分和评价。通过Kaplan-Meier分析比较所有患者的无手术生存时间。结果我们发现，与未佩戴SCL的患者相比，佩戴SCL的患者GDLD结节性病变的进展率显着较低（p=0.0179）。未观察到混浊和新生血管形成的抑制作用，未发现视力的显著改善（logMAR值，SCL-开启：平均值=-0.036，中位数=0; SCL-关闭：平均值=0.149，中位数=+0.088; p=0.14）。16只手术眼的无手术生存时间为2770 ± 1918天，明显长于22只手术眼的1342 ± 1323天（Kaplan-Meier分析，p=0.0007），这表明治疗性SCL延长了GDLD患者手术干预的时间，并减少了手术干预的必要性。结节性病变，并减少手术干预的需要。
Background/AimsTo investigate the efficacy of therapeutic soft contact lenses (SCLs) in gelatinous drop-like corneal dystrophy (GDLD) management.MethodsThis was a retrospective, consecutive, observational case series, including 20 patients (40 eyes) with GDLD treated in Osaka University Hospital within the last 15 years. We tested the effects of therapeutic SCL on clinical features, visual acuity and surgical interventions. Examinations for clinical features and visual acuity were done on patients who had no surgical intervention for 3 years. Scoring and evaluation of changes in three main clinical GDLD features and visual acuity (logMAR units) were performed using Fisher’s exact test and Mann-Whitney U test. Surgery-free survival time was compared by Kaplan-Meier analyses in all patients.ResultsWe found a significantly lower rate of progression in GDLD nodular lesions in patients wearing SCLs compared with those who did not (p=0.0179). No suppressant effects were observed regarding opacity and neovascularisation, and no significant improvements were found in visual acuity (in logMAR values, SCL-on: mean=− 0.036, median=0; SCL-off: mean=0.149, median=+ 0.088; p=0.14). The surgery-free survival time for all 16 SCL-on eyes was 2770 ± 1918 days, significantly longer than that for 22 SCL-off eyes, 1342 ± 1323 days (Kaplan-Meier analysis, p=0.0007), suggesting that therapeutic SCL extends the period until surgical intervention and reduces their necessity in patients with GDLD.ConclusionWearing therapeutic SCLs in GDLD slows the progression of nodular lesions and decreases the need for surgical interventions.
登录
查看更多内容
影响因子：
--
作者：
FANTES, FE;HANNA, KD;SAVOLDELLI, M
通讯作者：
SAVOLDELLI, M
隐形眼镜在角膜疾病中的应用
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
D. M. Robertson;H. Cavanagh
通讯作者：
H. Cavanagh
日本凝胶状水滴样角膜营养不良的一系列临床表现。
DOI：
--
发表时间：
2004
期刊：
American journal of ophthalmology-glaucoma
影响因子：
--
作者：
T. Ide;K. Nishida;N. Maeda;M. Tsujikawa;Shuji Yamamoto;Hitoshi Watanabe;Y. Tano
通讯作者：
Y. Tano
角膜缘干细胞移植治疗凝胶状水滴样角膜营养不良
影响因子：
2
作者：
H. Movahedan;Hamid Reza Anvari;M. Nowroozzadeh
通讯作者：
M. Nowroozzadeh
影响因子：
158.5
作者：
Nishida, K;Yamato, M;Tano, Y
通讯作者：
Tano, Y