Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila.

Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila.
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在果蝇中鉴定的血细胞库中达成共识。

DOI:
10.3389/fcell.2021.643712
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发表时间:
2021
影响因子:
5.5
通讯作者:
Giangrande A
Giangrande A
中科院分区:
生物学2区
文献类型:
--
作者:
Cattenoz PB;Monticelli S;Pavlidaki A;Giangrande A

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到目前为止,果蝇免疫细胞的分类仅限于三种主要细胞类型,基于形态、功能和很少的分子标记。最近的三项单细胞研究强调了几个亚群的存在,揭示了幼虫免疫细胞分子特征的巨大多样性。由于这些研究依赖于略有不同的实验和分析方法,我们在这里比较数据集,并确定与不同功能相关的八个共同的、强大的亚组,如增殖、免疫反应、吞噬或分泌。对不同时期和不同组织的数据集进行了类似的比较分析,揭示了类似于胚胎血细胞前体的幼虫免疫细胞的存在,以及与周围组织相关的幼虫免疫细胞中特定属性的表达。
The catalog of the Drosophila immune cells was until recently limited to three major cell types, based on morphology, function and few molecular markers. Three recent single cell studies highlight the presence of several subgroups, revealing a large diversity in the molecular signature of the larval immune cells. Since these studies rely on somewhat different experimental and analytical approaches, we here compare the datasets and identify eight common, robust subgroups associated to distinct functions such as proliferation, immune response, phagocytosis or secretion. Similar comparative analyses with datasets from different stages and tissues disclose the presence of larval immune cells resembling embryonic hemocyte progenitors and the expression of specific properties in larval immune cells associated with peripheral tissues.
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