Differential effects of oxytocin on mouse hippocampal oscillations in vitro
Differential effects of oxytocin on mouse hippocampal oscillations in vitro
复制标题
催产素对体外小鼠海马振荡的不同影响
DOI：
10.1111/ejn.13412
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发表时间：
2016
影响因子：
3.4
通讯作者：
Both M
中科院分区：
文献类型：
--
作者：
Maier P;Kaiser ME;Grinevich V;Draguhn A;Both M
下丘脑神经肽催产素（OT）控制分娩和哺乳，参与社会行为，在各种精神疾病中发挥作用，并对学习和记忆有影响。虽然OT的行为效应已被广泛研究，但对其对神经元和网络活动模式的影响知之甚少。在这里，我们研究了OT对小鼠海马脑片中海马网络活动的两种主要模式的影响。我们研究了γ频率振荡和尖波涟漪复合物（SPW-R）的不同体外模型，这两种模式分别与空间记忆形成和记忆巩固有关。引人注目的是，我们发现OT在这些不同的、相互排斥的活动模式上有着深刻的差异。虽然γ振荡不受海马OT受体激活的影响，但SPW-R被有效且快速地抑制。有趣的是，同时增强了振荡耦合尖峰的时间精度。因此，OT对不同的网络模式产生强烈不同的调节作用，最有可能是通过抑制不同的抑制性中间神经元。伽马和SPW-R振荡之间观察到的二分法可能对OT的行为和认知效应产生深远影响，这与认知过程和精神疾病有关。
The hypothalamic neuropeptide oxytocin (OT) controls childbirth and lactation, is involved in social behaviors, plays a role in various psychiatric disorders, and has effects on learning and memory. Although behavioral effects of OT have been extensively studied, much less is known about its effects on neuronal and network activity patterns. Here, we investigate the effect of OT on two major patterns of hippocampal network activity in mouse hippocampal slices. We studied differentin vitromodels of gamma‐frequency oscillations and sharp wave‐ripple complexes (SPW‐R), two patterns implicated in spatial memory formation and memory consolidation respectively. Strikingly, we found a profound difference of OT on these distinct, mutually exclusive activity patterns. While gamma oscillations where not affected by the activation of hippocampal OT receptors, SPW‐R were potently and rapidly suppressed. Interestingly, the temporal precision of oscillation‐coupled spikes was enhanced at the same time. Thus, OT exerts strongly different modulatory effects on different network patterns, most likely by inhibition of different sets of inhibitory interneurons. The observed dichotomy between gamma and SPW‐R oscillations may have profound effects on the behavioral and cognitive effects of OT which are relevant to cognitive processes and to psychiatric diseases.
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