Status of the "East Side hypothesis" (transovarial interference) 25 years later.
Status of the "East Side hypothesis" (transovarial interference) 25 years later.
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DOI：
10.1111/j.1749-6632.2009.04522.x
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发表时间：
2009-05
影响因子：
5.2
通讯作者：
Telford SR 3rd
中科院分区：
文献类型：
--
作者：
Telford SR 3rd
世纪初，在臭名昭著的比特鲁谷爆发的落基山斑疹热病例分布独特，几乎所有的病例都来自山谷的西侧。直到Burgdorfer等人（1981年）报道内共生立克次体在比特鲁河流域东侧而非西侧的木蜱中普遍存在时，这种分布才得到解释。据说，“东侧因子”可防止立克次体的经卵传播，从而严重限制了后者的流行。这一假说被认为是对流行病学难题最具创新性的解释之一，事实上，在医学昆虫学文献中已被普遍接受为事实。我审查的干扰假说的证据，并建议，Bitterroot谷RMSF爆发的分布实际上可能有其基础上的栖息地或小气候相关的因素，而不是反映种间竞争密切相关的立克次体。
Rocky Mountain Spotted Fever cases in the notorious Bitterroot Valley outbreak of the early 20th century were peculiarly distributed, with virtually all reported from the west side of the valley. Such a distribution remained unexplained until Burgdorfer et al (1981) reported that endosymbiotic rickettsiae were prevalent in wood ticks on the east side of the Bitterroot River valley but not on the west side. The “east side agent” was said to prevent the transovarial transmission of Rickettsia rickettsii, thereby severely limiting the prevalence of the latter. This hypothesis has been considered one of the most innovative explanations for an epidemiological conundrum, and indeed, has generally been accepted as a fact in the medical entomology literature. I review the evidence for the interference hypothesis, and suggest that the distribution of the Bitterroot Valley RMSF outbreak might actually have its basis in habitat or microclimate-related factors as opposed to reflecting interspecific competition by closely related rickettsiae.
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影响因子：
2.1
作者：
BURGDORFER, W
通讯作者：
BURGDORFER, W
影响因子：
6.4
作者：
Houhamdi, L;Fournier, PE;Raoult, D
通讯作者：
Raoult, D
影响因子：
3.3
作者：
PHILIP, CB
通讯作者：
PHILIP, CB
DOI：
10.1099/00207713-47-2-446
发表时间：
1997-04-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
Niebylski, ML;Schrumpf, ME;Schwan, TG
通讯作者：
Schwan, TG
DOI：
10.1196/annals.1374.064
发表时间：
2006-01-01
期刊：
CENTURY OF RICKETTSIOLOGY: EMERGING, REEMERGING RICKETTSIOSES, MOLECULAR DIAGNOSTICS, AND EMERGING VETERINARY RICKETTSIOSES
影响因子：
--
作者：
Carmichael, Jennifer R.;Fuerst, Paul A.
通讯作者：
Fuerst, Paul A.