Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.
Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.
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DOI：
10.1016/j.celrep.2019.05.018
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发表时间：
2019-06-04
期刊：
影响因子：
8.8
通讯作者：
Arlotta P
中科院分区：
文献类型：
--
作者：
Zonouzi M;Berger D;Jokhi V;Kedaigle A;Lichtman J;Arlotta P
神经元和少突胶质细胞之间的相互交流对于髓磷脂的产生和定位至关重要，髓磷脂是中枢神经系统的一个重要特征。在新皮层中，单个少突胶质细胞可形成多个轴突髓鞘；然而，髓鞘轴突的神经元起源仍然不明确，虽然主要假设来自兴奋性锥体神经元，但它也包括抑制性中间神经元。这就提出了一个问题，即单个少突胶质细胞是否对它们形成髓鞘的神经元类别有偏见。在这里，我们发现不同类型的皮质中间神经元从髓鞘形成开始就表现出不同的髓鞘分布模式，这表明少突胶质细胞可以识别它们所针对的单个类型的中间神经元的类别身份。值得注意的是，我们发现一些少突胶质细胞不成比例地髓鞘化抑制性中间神经元的轴突，而其他少突胶质细胞主要靶向兴奋性轴突，或者没有偏倚。这些结果指向了少突胶质细胞和神经元之间非常具体的相互作用，并提出了一个有趣的问题，即为什么髓鞘形成对不同神经元类型的定向不同。
Reciprocal communication between neurons and oligodendrocytes is essential for the generation and localization of myelin, a critical feature of the central nervous system. In the neocortex, individual oligodendrocytes can myelinate multiple axons; however, the neuronal origin of the myelinated axons has remained undefined, and while largely assumed to be from excitatory pyramidal neurons, it also includes inhibitory interneurons. This raises the question of whether individual oligodendrocytes display biases for the class of neurons that they myelinate. Here, we find that different classes of cortical interneurons show distinct patterns of myelin distribution starting from the onset of myelination, suggesting that oligodendrocytes can recognize the class identity of individual types of interneurons that they target. Notably, we show that some oligodendrocytes disproportionately myelinate the axons of inhibitory interneurons, while others primarily target excitatory axons, or show no bias. These results point towards very specific interactions between oligodendrocytes and neurons, and raise the interesting question of why myelination is differentially directed towards different neuron types.
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影响因子：
25
作者：
De Marco García NV;Priya R;Tuncdemir SN;Fishell G;Karayannis T
通讯作者：
Karayannis T
DOI：
10.1126/science.aac9462
发表时间：
2015-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang X;Shen S;Cadwell CR;Berens P;Sinz F;Ecker AS;Patel S;Tolias AS
通讯作者：
Tolias AS
影响因子：
64.8
作者：
Bock, Davi D.;Lee, Wei-Chung Allen;Kerlin, Aaron M.;Andermann, Mark L.;Hood, Greg;Wetzel, Arthur W.;Yurgenson, Sergey;Soucy, Edward R.;Kim, Hyon Suk;Reid, R. Clay
通讯作者：
Reid, R. Clay
影响因子：
64.8
作者：
Schmidt, Helene;Gour, Anjali;Helmstaedter, Moritz
通讯作者：
Helmstaedter, Moritz
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael