Nanoparticle modification in biological media: implications for oral nanomedicines.
Nanoparticle modification in biological media: implications for oral nanomedicines.
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作者：
纳米药物在口服吸收不良的药物，如生物制品方面显示出潜力。作为与优化纳米药物的安全性和有效性相关的过程的一部分，必须充分描述纳米粒子与包括肠道在内的生物系统的相互作用。在这篇文章中，我们提供了一个主要机制的概述，纳米粒子可能通过引入生物媒体的变化。具体地，讨论了缔合、溶解和生物分子吸附现象，以及影响每种现象发生的因素。还探讨了这些现象在纳米药物治疗作用的背景下的含义，包括靶向效率的降低。最后，我们将评论纳米颗粒在肠道环境中的修饰，包括目前可用于研究纳米生物相互作用的胃肠道模型，以及对口服纳米药物领域的启示。纳米药物在生物介质中发生转化，从而影响生物效应。肠道环境中的这种转变意味着将纳米药物用于口服给药。
Nanomedicine has shown potential in enabling oral administration of poorly absorbable drugs, such as biologics. As part of the process related to optimisation of the safety and efficacy of nanomedicines, it is imperative that the interaction of nanoparticles with the biological systems – including the gut – is fully characterised. In this article, we provide an overview of the major mechanisms by which nanoparticles may transform upon introduction in biological media. Specifically, the phenomena of association, dissolution and biomolecule adsorption are discussed, together with factors which influence the occurrence of each phenomenon. The implications of these phenomena within the context of therapeutic action of nanomedicines, which includes reduced targeting efficiency, are also explored. Finally, we will comment on nanoparticle modification within the gut environment, including the currently available gastrointestinal models for the study of nano-bio interactions, with implications in the area of nanomedicines for oral administration. Nanomedicines undergo transformation in biological media, which impacts biological effects. Such transformation in the gut environment has implications in use of nanomedicines for oral administration.
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影响因子：
4.4
作者：
Christensen J;El-Gebali S;Natoli M;Sengstag T;Delorenzi M;Bentz S;Bouzourene H;Rumbo M;Felsani A;Siissalo S;Hirvonen J;Vila MR;Saletti P;Aguet M;Anderle P
通讯作者：
Anderle P
DOI：
10.1002/wnan.1333
发表时间：
2015-09
期刊：
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
影响因子：
--
作者：
Bellmann S;Carlander D;Fasano A;Momcilovic D;Scimeca JA;Waldman WJ;Gombau L;Tsytsikova L;Canady R;Pereira DI;Lefebvre DE
通讯作者：
Lefebvre DE
影响因子：
3.9
作者：
Bian, Shao-Wei;Mudunkotuwa, Imali A.;Grassian, Vicki H.
通讯作者：
Grassian, Vicki H.
影响因子：
14
作者：
Gagner, Jennifer E.;Lopez, Marimar D.;Siegel, Richard W.
通讯作者：
Siegel, Richard W.
影响因子：
17.1
作者：
Albanese, Alexandre;Chan, Warren C. W.
通讯作者：
Chan, Warren C. W.