Estrogen Regulation of MicroRNA Expression.
Estrogen Regulation of MicroRNA Expression.
复制标题
DOI：
10.2174/138920209788185289
复制
发表时间：
2009-05
期刊：
影响因子：
2.6
通讯作者：
Klinge CM
中科院分区：
文献类型：
--
作者：
Klinge CM
女性比男性长寿，但预期寿命不受激素替代疗法（雌激素+维生素E）的影响。雌激素似乎可以保护大脑、心血管组织和骨骼免受衰老。雌激素通过与雌激素受体α和β（ERα和ERβ）（配体激活的转录因子）结合直接调节基因，并通过激活质膜相关的ER间接调节基因，后者进而激活细胞内信号级联，导致基因表达改变。微小RNA（miRNAs）是短的（19-25个核苷酸）、天然存在的、非编码RNA分子，其与靶mRNA的3'非翻译区碱基配对。这种相互作用要么阻断mRNA的翻译，要么靶向待降解的mRNA转录物。人类基因组包含约700- 1，200个miRNA。miRNA表达的异常模式与包括乳腺癌在内的人类疾病有关。最近的研究已经在人乳腺癌细胞、人子宫内膜间质和子宫肌层平滑肌细胞、大鼠乳腺和小鼠子宫中鉴定出受雌激素调节的miRNA。绝经后妇女雌二醇水平的下降与各种年龄相关疾病有关。雌激素调节的miRNA表达的作用、这些miRNA的靶基因以及miRNA在衰老中的作用还有待探索。
Women outlive men, but life expectancy is not influenced by hormone replacement (estrogen + progestin) therapy. Estrogens appear to protect brain, cardiovascular tissues, and bone from aging. Estrogens regulate genes directly through binding to estrogen receptors alpha and beta (ERα and ERβ) that are ligand-activated transcription factors and indirectly by activating plasma membrane-associated ER which, in turns, activates intracellular signaling cascades leading to altered gene expression. MicroRNAs (miRNAs) are short (19-25 nucleotides), naturally-occurring, non-coding RNA molecules that base-pair with the 3’ untranslated region of target mRNAs. This interaction either blocks translation of the mRNA or targets the mRNA transcript to be degraded. The human genome contains ~ 700-1,200 miRNAs. Aberrant patterns of miRNA expression are implicated in human diseases including breast cancer. Recent studies have identified miRNAs regulated by estrogens in human breast cancer cells, human endometrial stromal and myometrial smooth muscle cells, rat mammary gland, and mouse uterus. The decline of estradiol levels in postmenopausal women has been implicated in various age-associated disorders. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in aging has yet to be explored.
登录
查看更多内容
影响因子：
4.8
作者：
Belcher, SM;Le, HH;Wong, JK
通讯作者：
Wong, JK
影响因子：
4
作者：
Cheskis, BJ
通讯作者：
Cheskis, BJ
影响因子：
30.8
作者：
Carroll, Jason S.;Meyer, Clifford A.;Brown, Myles
通讯作者：
Brown, Myles
影响因子：
4.8
作者：
Adams, Brian D.;Claffey, Kevin P.;White, Bruce A.
通讯作者：
White, Bruce A.
影响因子：
--
作者：
Chambliss, KL;Simon, L;Shaul, PW
通讯作者：
Shaul, PW