Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation.
Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation.
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IL-6 和皮质醇活性对总血浆纤维蛋白浓度和急性精神应激诱导的纤维蛋白形成的不同贡献。
作者：
R. von Känel;B. Kudielka;D. Hanebuth;D. Preckel;J. Fischer
急性精神压力可能通过影响炎症和凝血而导致动脉粥样硬化；然而，应激过程中炎症和凝血之间的相互作用尚未得到研究。在本研究中，我们研究了血浆纤维蛋白原、血浆 IL-6（白细胞介素 6）和游离唾液皮质醇与促凝血标志物 D-二聚体的关联，反映了 2 小时内的纤维蛋白形成以及对急性精神应激的反应。 21 名男性志愿者（平均年龄，47+/-8 岁）接受了特里尔社会压力测试，包括 3 分钟准备阶段、5 分钟工作面试和 5 分钟观众面前的心算测试。在应激前后以及应激恢复 45 分钟和 105 分钟后立即测量 IL-6、纤维蛋白原、D-二聚体和皮质醇。计算曲线下的两个不同面积，以获得整个 2 小时内总蛋白质活性和蛋白质应激反应性的综合测量。根据方差分析确定，IL-6 (P < 0.001)、纤维蛋白原 (P = 0.001)、D-二聚体 (P = 0.021) 和皮质醇 (P < 0.001) 在评估的四个时间点均发生显着变化。在整个 2 小时内，总纤维蛋白原活性 (R2 = 0.33，P = 0.007) 和总皮质醇活性 (DeltaR2 = 0.17，P = 0.034) 解释了总 D-二聚体活性差异的 50%。应激引起的纤维蛋白原 (R2 = 0.47，P = 0.001) 和 IL-6 (DeltaR2 = 0.18，P = 0.008) 变化共同解释了 D-二聚体对应激反应性差异的 65%。纤维蛋白原和下丘脑-垂体-肾上腺活性独立预测总纤维蛋白形成。促炎和促凝血变化与压力相关。除了纤维蛋白原反应性之外，IL-6 反应性是应激诱导的纤维蛋白形成的独立预测因子。
Acute mental stress may contribute to atherosclerosis by affecting inflammation and coagulation; however, the crosstalk between inflammation and coagulation during stress has not been studied. In the present study, we investigated the association of plasma fibrinogen, plasma IL-6 (interleukin-6) and free salivary cortisol with the procoagulant marker D-dimer reflecting fibrin formation both over a 2-h period and in response to acute mental stress. Twenty-one male volunteers (mean age, 47+/-8 years) underwent the Trier Social Stress Test combining a 3-min preparation phase, a 5-min job interview and 5-min mental arithmetic test before an audience. IL-6, fibrinogen, D-dimer and cortisol were measured immediately before and after stress, and after 45 min and 105 min of recovery from stress. Two distinct areas under the curve were computed to obtain integrated measures of total protein activity over the entire 2-h period and of stress reactivity of proteins. IL-6 (P < 0.001), fibrinogen (P = 0.001), D-dimer (P = 0.021) and cortisol (P < 0.001) had all significantly changed across the four time points assessed, as determined by ANOVA. For the entire 2-h period, total fibrinogen activity (R2 = 0.33, P = 0.007) and total cortisol activity (DeltaR2 = 0.17, P = 0.034) explained 50% of the variance in total D-dimer activity. Stress-induced changes in fibrinogen (R2 = 0.47, P = 0.001) and IL-6 (DeltaR2 = 0.18, P = 0.008) together explained 65% of the variance in D-dimer reactivity to stress. Total fibrin formation was independently predicted by fibrinogen and hypothalamo-pituitary-adrenal activity. Pro-inflammatory and procoagulant changes with stress were associated. Aside from fibrinogen reactivity, IL-6 reactivity was an independent predictor of stress-induced fibrin formation.
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影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
影响因子：
5.9
作者：
Cohen, HJ;Harris, T;Pieper, CF
通讯作者：
Pieper, CF
影响因子：
37.8
作者：
Ridker, PM;Rifai, N;Hennekens, CH
通讯作者：
Hennekens, CH
β2-肾上腺素能受体功能和去甲肾上腺素增加对精神压力引起的高凝状态的影响。
影响因子：
4.8
作者：
vonKänel,Roland;Mills,PaulJ;Ziegler,MichaelG;Dimsdale,JoelE
通讯作者：
Dimsdale,JoelE