Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohort.
Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohort.
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世界贸易中心队列中多环芳烃，环境烟草烟雾与儿童发育之间的关系。
DOI：
10.1289/ehp.10144
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发表时间：
2007-10
影响因子：
10.4
通讯作者：
Lederman, Sally Ann
中科院分区：
文献类型：
--
作者：
Perera, Frederica P.;Tang, Deliang;Rauh, Virginia;Tu, Yi Hsuan;Tsai, Wei Yann;Becker, Mark;Stein, Janet L.;King, Jeffrey;Del Priore, Giuseppe;Lederman, Sally Ann
多环芳烃（PAHs），包括苯并[a]芘（BaP），是世界贸易中心（WTC）火灾和城市燃烧源释放的空气污染物。BaP-DNA加合物提供了多环芳烃特异性遗传损伤的测量方法，这与不良出生结果和癌症的风险增加有关。我们之前报道过，在911事件后一个月内居住在世贸中心遗址1英里范围内的受试者，分娩时获得的母体和脐带血中的BaP-DNA加合物水平升高；血液加合物升高与子宫内暴露于环境烟草烟雾（ETS）与胎儿生长下降显著相关。我们的目的是评估产前接触WTC污染物对儿童发育的可能影响。2001年9月11日之后，我们招募了一组在曼哈顿下城三家医院分娩的不吸烟孕妇。我们跟踪了一组孩子，直到他们三岁生日，并使用贝利儿童发展量表（BSID-II）测量了他们的认知和运动发展。在多变量分析中，我们发现脐带血加合物和子宫内接触ETS对3岁儿童智力发展指数评分有显著的相互作用（p = 0.02, n = 98），而加合物和ETS单独都不是（BSID-II）认知发展的显著预测因子。虽然数量有限，但这些结果表明，暴露于高水平的多环芳烃与产前暴露于ETS可能导致队列儿童认知发育的适度降低。
Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP–DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP–DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposure to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth. Our aim was to assess possible effects of prenatal exposure to WTC pollutants on child development. After 11 September 2001, we enrolled a cohort of nonsmoking pregnant women who delivered at three lower Manhattan hospitals. We have followed a subset of children through their third birthdays and measured cognitive and motor development using the Bayley-II Scales of Child Development (BSID-II). In multivariate analyses, we found a significant interaction between cord blood adducts and in utero exposure to ETS on mental development index score at 3 years of age (p = 0.02, n = 98) whereas neither adducts nor ETS alone was a significant predictor of (BSID-II) cognitive development. Although limited by small numbers, these results suggest that exposure to elevated levels of PAHs in conjunction with prenatal ETS exposure may have contributed to a modest reduction in cognitive development among cohort children.
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影响因子：
10.4
作者：
McGee JK;Chen LC;Cohen MD;Chee GR;Prophete CM;Haykal-Coates N;Wasson SJ;Conner TL;Costa DL;Gavett SH
通讯作者：
Gavett SH
影响因子：
10.4
作者：
Lioy PJ;Weisel CP;Millette JR;Eisenreich S;Vallero D;Offenberg J;Buckley B;Turpin B;Zhong M;Cohen MD;Prophete C;Yang I;Stiles R;Chee G;Johnson W;Porcja R;Alimokhtari S;Hale RC;Weschler C;Chen LC
通讯作者：
Chen LC
影响因子：
7.5
作者：
Gill, B;Chang, J;Palmer, S
通讯作者：
Palmer, S
影响因子：
158.5
作者：
JANERICH, DT;THOMPSON, WD;MCKNEALLY, MF
通讯作者：
MCKNEALLY, MF
影响因子：
10.4
作者：
LEIKAUF, GD;KLINE, S;BUNCHER, CR
通讯作者：
BUNCHER, CR