The relationship between airway responsiveness to histamine and pulmonary function level in a random population sample.
The relationship between airway responsiveness to histamine and pulmonary function level in a random population sample.
复制标题
随机人群样本中气道对组胺的反应性与肺功能水平之间的关系。
DOI：
--
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
R. Lende
中科院分区：
文献类型：
--
作者：
B. Rijcken;J. Schouten;S. Weiss;F. Speizer;R. Lende
在荷兰进行的慢性阻塞性肺疾病现场调查中，随机抽取了2,156名年龄在15岁至之间的男女受试者，研究了非特异性支气管反应性(BR)与肺功能水平的关系。约25%的受试者在吸入浓度为16 mg/ml或更低的组胺后，基础FEV_1下降10%或更多，吸入S(PC10)以上。在分层分析中，肺功能水平似乎与BR呈剂量-反应关系。在反应较快的受试者中，平均%FEV1始终较低。在调整了年龄、性别、居住地和吸烟习惯的线性回归分析中，这种关系得到了证实。排除%FEV1小于80%的受试者减少了，但没有改变FEV1和BR之间的关联。反应性对肺功能水平的影响程度相当大，具有统计学意义。在21岁以上的受试者中，男性应答者(PC10值小于或等于16 mg/ml)的调整后FEV1比无应答者平均少32.5%，女性应答者的调整后FEV1少30.5%(p<0.001)。在调整了年龄、性别、居住地、呼吸道症状患病率和吸烟因素后，BR似乎是肺功能水平的独立预测因子。在这一人群样本中，吸烟对肺功能水平的影响仅在21岁以上的男性中显著。
The association of nonspecific bronchial responsiveness (BR) with pulmonary function level has been studied in a random population sample of 2,156 male and female subjects 15 to 64 yr of age participating in the Vlagtwedde-Vlaardingen field survey on chronic obstructive pulmonary disease (COPD) being conducted in the Netherlands. About 25% of the subjects responded with a decrease in baseline FEV1 of 10% or more after challenge with histamine in a concentration of 16 mg/ml or less inhaled over 30 s (PC10). In a stratified analysis, pulmonary function level appeared to be associated with BR in a dose-response relationship. The mean %FEV1 was consistently lower in the more responsive subjects. This relationship was confirmed in linear regression analyses, adjusting for age, sex, area of residence, and smoking habits. Exclusion of subjects with %FEV1 less than 80% diminished but did not change the association between FEV1 and BR. The magnitude of the effect of responsiveness on level of pulmonary function was considerable and statistically significant. In the subjects older than 21 yr of age, male responders (PC10 at less than or equal to 16 mg/ml) on average had an adjusted FEV1 of 32.5 centiliters less than nonresponders, and female responders had an adjusted FEV1 of 30.5 centiliters less (p less than 0.001). BR appeared to be an independent predictor of pulmonary function level after adjustment for age, sex, area of residence, respiratory symptom prevalence, and cigarette smoking. The effect of cigarette smoking on pulmonary function level in this population sample was significant only in men older than 21 yr of age.(ABSTRACT TRUNCATED AT 250 WORDS)
DOI：
10.1164/arrd.1980.122.5.709
发表时间：
2015-05
期刊：
The American review of respiratory disease
影响因子：
--
作者：
B. Burrows;F. Hasan;R. Barbee;M. Halonen;M. Lebowitz
通讯作者：
B. Burrows;F. Hasan;R. Barbee;M. Halonen;M. Lebowitz
成人气道对冷空气、吸烟和过敏性反应与呼吸道症状和肺功能的关系。
DOI：
10.1164/arrd.1984.130.2.198
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Welty,C;Weiss,ST;Tager,IB;Munoz,A;Becker,C;Speizer,FE;IngramJr,RH
通讯作者：
IngramJr,RH