Increased serum brain-derived neurotrophic factor protein upon hypoxia in healthy young men
Increased serum brain-derived neurotrophic factor protein upon hypoxia in healthy young men
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健康年轻男性缺氧时血清脑源性神经营养因子蛋白增加
DOI：
10.1007/s00702-009-0257-2
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发表时间：
2009
影响因子：
3.3
通讯作者：
Oltmanns KM
中科院分区：
文献类型：
--
作者：
Hubold C;Lang UE;Gehring H;Schultes B;Schweiger U;Born J;Fehm HL;Peters A;Hellweg R;Oltmanns KM
将动物暴露于短暂的低氧期导致称为预处理的神经保护性缺血耐受。这种现象在大脑中有很好的记录，但潜在的机制需要进一步阐明。由于神经生长因子（NGF）和脑源性神经营养因子（BDNF）是维持成人神经系统内环境稳定的重要介质，我们推测低氧预处理可能会调节血清神经营养因子浓度。在14名健康青年男子中诱导低氧30分钟，导致恒定的血氧饱和度为75%。进行高胰岛素正葡萄糖钳夹，并在基线、干预后即刻和疗程结束时测量血清BDNF和NGF浓度。总体而言，血清BDNF浓度随时间下降最大35%（P= 0.001），而相反，NGF浓度保持不变。急性缺氧可减轻脑源性神经营养因子的下降，使脑源性神经营养因子的含量显著高于常氧对照组（P< 0.01）。我们的研究结果表明，急性缺氧导致显着较高的血清BDNF浓度指向的潜在作用，BDNF在缺氧预适应的潜在机制。基于其神经保护特性，BDNF可能在缺血性神经血管疾病的治疗选择中具有高度的临床相关性。
Exposing animals to brief hypoxic periods leads to neuroprotective ischemic tolerance termed preconditioning. This phenomenon is well documented in the brain, but the underlying mechanisms require further elucidation. As nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important mediators of maintaining homeostatic conditions in the adult nervous system in terms of physiological and pathophysiological processes, we hypothesized that hypoxic preconditioning might modulate serum neurotrophin concentrations. Hypoxia was induced for 30 min in 14 healthy young men resulting in a constant blood oxygen saturation of 75%. Hyperinsulinemic euglycemic clamps were performed and serum concentrations of BDNF and NGF were measured at baseline, directly after the intervention, and at the end of the session. Overall, serum BDNF concentrations decreased over time by maximally 35% (P= 0.001) while in contrast NGF concentrations remained unchanged. Acute hypoxia alleviated the decrease of BDNF resulting in higher BDNF concentrations as compared to normoxic control (P< 0.01). Our findings show that acute hypoxia results in significantly higher serum BDNF concentrations pointing to a potential role of BDNF in the underlying mechanism of hypoxic preconditioning. Based on its neuroprotective properties, BDNF may be of high clinical relevance for therapeutic options in ischemic neurovascular diseases.
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影响因子：
2.9
作者：
L. Stanzani;C. Zoia;G. L. Sala;I. Appollonio;L. Frattola;M. D. Simoni;C. Ferrarese
通讯作者：
L. Stanzani;C. Zoia;G. L. Sala;I. Appollonio;L. Frattola;M. D. Simoni;C. Ferrarese
影响因子：
4
作者：
Begliuomini, Silvia;Lenzi, Elena;Genazzani, Andrea R.
通讯作者：
Genazzani, Andrea R.
轻度缺氧（2200 m）对儿茶酚胺和皮质酮分泌的影响。
DOI：
--
发表时间：
1975
期刊：
Physiologie
影响因子：
--
作者：
P. Groza;C. Vlǎdescu;J. Boerescu
通讯作者：
J. Boerescu
研究人员致力于改善急性缺血性中风的治疗。
DOI：
--
发表时间：
2006
期刊：
Journal of the American Medical Association (JAMA)
影响因子：
--
作者：
M. Mitka
通讯作者：
M. Mitka
影响因子：
5.3
作者：
Hellweg, R;von Arnim, CAF;Riepe, MW
通讯作者：
Riepe, MW