Executive function in Parkinson's disease: set-shifting or set-maintenance?
Executive function in Parkinson's disease: set-shifting or set-maintenance?
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帕金森病的执行功能：定势转移还是定势维持？
DOI：
10.1080/01688639308402562
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发表时间：
1993
影响因子：
2.2
通讯作者：
Stern,Y
中科院分区：
文献类型：
--
作者：
Richards,M;Cote,LJ;Stern,Y
为了区分帕金森氏病（PD）的设置转移障碍与无法抑制由竞争注意力的刺激引起的注意力分散，18名患有特发性PD的非痴呆患者和13名年龄和教育程度相等的正常对照，进行了Odd-Man Out （OMO）测试和Stroop颜色-单词测试。PD患者在OMO测试中明显受损，但在Stroop测试中没有显示出干扰的证据。对OMO测试期间错误模式的分析表明，反复切换规则的需求，而不是在规则切换之间保持稳定响应的需求，是导致OMO性能受损的原因。结论是OMO测试本质上是一个集合移位的测试，而不是PD中集合维持的测试。此外，对更大样本PD患者的分析显示，锥体外系症状的数量和严重程度与OMO错误产生之间存在显著正相关，后者与整体心理功能之间存在显著正相关。这些关系是相互独立的，表明PD患者的集移功能障碍可能是由额纹状体系统的病理引起的，独立于认知能力的变化。
In order to distinguish impairment in set-shifting in Parkinson's disease (PD) from inability to inhibit distraction by stimuli that compete for attention, 18 nondemented patients with idiopathic PD and 13 normal controls equated for age and education, were administered the Odd-Man Out (OMO) test and the Stroop Color-Word Test. PD patients were significantly impaired on the OMO test but showed no evidence of interference during the Stroop test. Analysis of error patterns during the OMO test indicated that the requirement to repeatedly switch rules, rather than the requirement to maintain steady responding between rule switches, was responsible for impaired OMO performance. It is concluded that the OMO test is fundamentally a test of set shifting, rather than a test of set maintenance in PD. In addition, analysis of a larger sample of PD patients revealed a significant positive relationship between number and severity of extrapyramidal signs and error production on the OMO, and between the latter and global mental function. These relationships were independent of each other, suggesting that impairment in set-shifting function in PD may arise from pathology of the fronto-striatal system independently of changes in cognitive ability.
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发病年龄对帕金森病神经心理学表现的影响。
DOI：
10.1136/jnnp.51.2.244
发表时间：
1988
期刊：
Journal of Neurology, Neurosurgery & Psychiatry
影响因子：
--
作者：
M. Hietanen;H. Teräväinen
通讯作者：
H. Teräväinen
DOI：
--
发表时间：
1977
期刊：
--
影响因子：
--
作者：
W. Schneider;R. Shiffrin
通讯作者：
W. Schneider;R. Shiffrin
MRI早期诊断单纯疱疹脑炎
影响因子：
9.9
作者：
G. Schroth;J. Gawehn;A. Thron;A. Vallbracht;K. Voigt
通讯作者：
K. Voigt
帕金森病的认知和运动功能障碍。
影响因子：
--
作者：
D. Lichter;A. Corbett;G. Fitzgibbon;O. Davidson;J. Hope;G. V. Goddard;K. Sharples;M. Pollock
通讯作者：
M. Pollock
影响因子：
9.9
作者：
BOWEN, FP;KAMIENNY, RS;YAHR, MD
通讯作者：
YAHR, MD