Dopamine regulates mobilization of mesenchymal stem cells during wound angiogenesis.
Dopamine regulates mobilization of mesenchymal stem cells during wound angiogenesis.
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DOI：
10.1371/journal.pone.0031682
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Basu S
中科院分区：
文献类型：
--
作者：
Shome S;Dasgupta PS;Basu S
Angiogenesis is an important step in the complex biological and molecular events leading to successful healing of dermal wounds. Among the different cellular effectors of wound angiogenesis, the role of mesenchymal stem cells (MSCs) is of current interest due to their transdifferentiation and proangiogenic potentials. Skin is richly innervated by sympathetic nerves which secrete dopamine (DA) and we have recently shown that concentration of DA present in synaptic cleft can significantly inhibit wound tissue neovascularization. As recent reports indicate that MSCs by mobilizing into wound bed play an important role in promoting wound angiogenesis, we therefore investigated the effect of DA on the migration of MSCs in wound tissues. DA acted through its D2 receptors present in the MSCs to inhibit their mobilization to the wound beds by suppressing Akt phosphorylation and actin polymerization. In contrast, this inhibitory effect of DA was reversed after treatment with specific DA D2 receptor antagonist. Increased mobilization of MSCs was demonstrated in the wound site following blockade of DA D2 receptor mediated actions, and this in turn was associated with significantly more angiogenesis in wound tissues. This study is of translational value and indicates use of DA D2 receptor antagonists to stimulate mobilization of these stem cells for faster regeneration of damaged tissues.
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影响因子：
3.3
作者：
Ding, Dah-Ching;Shyu, Woei-Cherng;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
影响因子：
5.2
作者：
Kasper, Grit;Dankert, Niels;Duda, Georg N.
通讯作者：
Duda, Georg N.
影响因子：
56.9
作者：
EWING, AG;BIGELOW, JC;WIGHTMAN, RM
通讯作者：
WIGHTMAN, RM
影响因子：
6
作者：
Ganguly, Subhalakshmi;Basu, Biswarup;Basu, Sujit
通讯作者：
Basu, Sujit
DOI：
10.1016/j.bbrc.2005.06.116
发表时间：
2005-08-26
影响因子：
3.1
作者：
Fiedler, J;Leucht, F;Brenner, RE
通讯作者：
Brenner, RE