Memorial familiarity remains intact for pictures but not for words in patients with amnestic mild cognitive impairment.
Memorial familiarity remains intact for pictures but not for words in patients with amnestic mild cognitive impairment.
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DOI：
10.1016/j.neuropsychologia.2012.06.001
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发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Ally BA
中科院分区：
文献类型：
--
作者：
Embree LM;Budson AE;Ally BA
了解记忆如何在阿尔茨海默病（AD）过程的早期阶段崩溃，无论是在临床还是在干预开发方面都具有重要意义。先前的工作已经强调了健全性轻度认知障碍（aMCI）患者的强大的图像优势效应。然而，在这群患者中，图片与文字相比是如何提高记忆力的，目前还不清楚。在本研究中，我们利用受试者工作特征（ROC）曲线来估计aMCI患者和健康老年对照者对图片和文字的熟悉度和回忆。准确度分析表明，即使在健康对照组中图像和文字的表现相匹配时，aMCI患者仍然表现出显著的图像优势效应。ROC分析结果显示，与对照组相比，患者的记忆和词汇熟悉度明显受损。相比之下，与对照组相比，aMCI患者表现出记忆力受损，但对图片的熟悉程度完好无损。基于我们实验室之前的工作，我们推测患者可以利用图片提供的丰富的概念信息来增强熟悉度，而感知信息可能允许检索后监测或验证增强的熟悉感。另外，测试项目的概念和感知流畅性增强的结合可能会驱动更强或更强大的熟悉感，这可以准确地归因于所研究的项目。
Understanding how memory breaks down in the earliest stages of the Alzheimer’s disease (AD) process has significant implications, both clinically and with respect to intervention development. Previous work has highlighted a robust picture superiority effect in patients with amnestic mild cognitive impairment (aMCI). However, it remains unclear as to how pictures improve memory compared to words in this patient population. In the current study, we utilized receiver operating characteristic (ROC) curves to obtain estimates of familiarity and recollection for pictures and words in patients with aMCI and healthy older controls. Analysis of accuracy shows that even when performance is matched between pictures and words in the healthy control group, patients with aMCI continue to show a significant picture superiority effect. The results of the ROC analysis showed that patients demonstrated significantly impaired recollection and familiarity for words compared controls. In contrast, patients with aMCI demonstrated impaired recollection, but intact familiarity for pictures, compared to controls. Based on previous work from our lab, we speculate that patients can utilize the rich conceptual information provided by pictures to enhance familiarity, and perceptual information may allow for post-retrieval monitoring or verification of the enhanced sense of familiarity. Alternatively, the combination of enhanced conceptual and perceptual fluency of the test item might drive a stronger or more robust sense of familiarity that can be accurately attributed to a studied item.
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