CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
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CpG 寡脱氧核苷酸可作为佐剂，开启辅助性 T 细胞 1 (Th1) 免疫。
DOI：
10.1084/jem.186.10.1623
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发表时间：
1997-11-17
期刊：
影响因子：
--
通讯作者：
Harding CV
中科院分区：
文献类型：
--
作者：
Chu RS;Targoni OS;Krieg AM;Lehmann PV;Harding CV
Synthetic oligodeoxynucleotides (ODN) that contain unmethylated CpG motifs (CpG ODN) induce macrophages to secrete IL-12, which induces interferon (IFN)-γ secretion by natural killer (NK) cells. Since these cytokines can induce T helper 1 (Th1) differentiation, we examined the effects of coadministered CpG ODN on the differentiation of Th responses to hen egg lysozyme (HEL). In both BALB/c (Th2-biased) and B10.D2 (Th1-biased) mice, immunization with HEL in incomplete Freund's adjuvant (IFA) resulted in Th2-dominated immune responses characterized by HEL-specific secretion of IL-5 but not IFN-γ. In contrast, immunization with IFA-HEL plus CpG ODN switched the immune response to a Th1-dominated cytokine pattern, with high levels of HEL-specific IFN-γ secretion and decreased HEL-specific IL-5 production. IFA-HEL plus CpG ODN also induced anti-HEL IgG2a (a Th1-associated isotype), which was not induced by IFA-HEL alone. Control non–CpG ODN did not induce IFN-γ or IgG2a, excepting lesser increases in B10.D2 (Th1-biased) mice. Thus, CpG ODN provide a signal to switch on Th1-dominated responses to coadministered antigen and are potential adjuvants for human vaccines to elicit protective Th1 immunity.
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影响因子：
15.3
作者：
Heinzel, F P;Schoenhaut, D S;Rerko, R M;Rosser, L E;Gately, M K
通讯作者：
Gately, M K
DOI：
10.1084/jem.169.1.59
发表时间：
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期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
Locksley RM
影响因子：
4.3
作者：
Halpern, MD;Kurlander, RJ;Pisetsky, DS
通讯作者：
Pisetsky, DS
DOI：
10.1073/pnas.93.7.2879
发表时间：
1996-04-02
影响因子：
11.1
作者：
Klinman, DM;Yi, AK;Krieg, AM
通讯作者：
Krieg, AM
DOI：
10.1016/0167-5699(95)80004-2
发表时间：
1995-08-01
期刊：
IMMUNOLOGY TODAY
影响因子：
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作者：
KELSO, A
通讯作者：
KELSO, A