Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men
Double transcranial direct current stimulation of the brain increases cerebral energy levels and systemic glucose tolerance in men
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双经颅直流电刺激大脑可增加男性的脑能量水平和全身葡萄糖耐量
DOI：
10.1111/jne.12688
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发表时间：
2019
影响因子：
3.2
通讯作者：
Oltmanns
中科院分区：
文献类型：
--
作者：
Wardzinski;Friedrichsen;Dannenberger;Kistenmacher;Melchert;Jauch-Chara;Oltmanns
经颅直流电刺激（tDCS）是一种神经调节方法，已通过实验测试，并已被用作治疗许多神经系统疾病和神经精神疾病的辅助治疗选择。除了其众所周知的脑内局部效应外，tDCS还短暂促进全身葡萄糖摄取并降低神经激素应激轴的活性。我们的目的是测试单次tDCS应用的效果是否可以在双重刺激后复制，以持续改善人体的全身葡萄糖耐量和应激轴活性。在一项单盲交叉研究中，我们检查了15名健康男性志愿者。连续两次应用阳极tDCS与假手术。通过标准高胰岛素-正常血糖葡萄糖钳夹程序研究全身葡萄糖耐量，并测量神经激素应激轴活性参数。由于tDCS诱导的脑能量消耗已被证明是假设效应的机制的一部分，我们通过31磷磁共振波谱监测了脑高能磷酸盐ATP和磷酸肌酸。正如假设的那样，分析显示，与假手术相比，双阳极tDCS持续增加葡萄糖耐量。此外，我们观察到双tDCS后脑高能磷酸盐含量显著升高。因此，与假手术相比，tDCS后神经激素应激轴的活性降低。我们的数据表明，在健康人中，双tDCS促进全身葡萄糖摄取并降低应激轴活性。这些作用表明，重复tDCS可能是未来对抗2型糖尿病患者葡萄糖耐受不良的非药物选择。
Transcranial direct current stimulation (tDCS) is a neuromodulatory method that has been tested experimentally and has already been used as an adjuvant therapeutic option to treat a number of neurological disorders and neuropsychiatric diseases. Beyond its well known local effects within the brain, tDCS also transiently promotes systemic glucose uptake and reduces the activity of the neurohormonal stress axes. We aimed to test whether the effects of a single tDCS application could be replicated upon double stimulation to persistently improve systemic glucose tolerance and stress axes activity in humans. In a single‐blinded cross‐over study, we examined 15 healthy male volunteers. Anodal tDCS vs sham was applied twice in series. Systemic glucose tolerance was investigated by the standard hyperinsulinaemic‐euglycaemic glucose clamp procedure, and parameters of neurohormonal stress axes activity were measured. Because tDCS‐induced brain energy consumption has been shown to be part of the mechanism underlying the assumed effects, we monitored the cerebral high‐energy phosphates ATP and phosphocreatine by31phosphorus magnetic resonance spectroscopy. As hypothesised, analyses revealed that double anodal tDCS persistently increases glucose tolerance compared to sham. Moreover, we observed a significant rise in cerebral high‐energy phosphate content upon double tDCS. Accordingly, the activity of the neurohormonal stress axes was reduced upon tDCS compared to sham. Our data demonstrate that double tDCS promotes systemic glucose uptake and reduces stress axes activity in healthy humans. These effects suggest that repetitive tDCS may be a future non‐pharmacological option for combating glucose intolerance in type 2 diabetes patients.
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影响因子：
3.4
作者：
Boros, Klara;Poreisz, Csaba;Nitsche, Michael A.
通讯作者：
Nitsche, Michael A.
DOI：
10.1016/s0140-6736(80)90388-8
发表时间：
1980
期刊：
The Lancet
影响因子：
--
作者：
O. Fakhri;A. Fadhli;RafiM. El Rawi
通讯作者：
RafiM. El Rawi
影响因子：
13.5
作者：
Banks, William A.;Owen, Joshua B.;Erickson, Michelle A.
通讯作者：
Erickson, Michelle A.
影响因子：
7.7
作者：
Kistenmacher, Alina;Manneck, Sebastian;Oltmanns, Kerstin M.
通讯作者：
Oltmanns, Kerstin M.
影响因子：
15.9
作者：
Kishore, Preeti;Boucai, Laura;Hawkins, Meredith
通讯作者：
Hawkins, Meredith