Management and Early Outcomes of Neonates Born to Women with SARS-CoV-2 in 16 U.S. Hospitals.
Management and Early Outcomes of Neonates Born to Women with SARS-CoV-2 in 16 U.S. Hospitals.
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DOI：
10.1055/s-0041-1726036
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发表时间：
2021-05
影响因子：
2
通讯作者：
Better Outcomes through Research for Newborns (BORN) Network
中科院分区：
文献类型：
--
作者：
Congdon JL;Kair LR;Flaherman VJ;Wood KE;LoFrumento MA;Nwaobasi-Iwuh E;Phillipi CA;Better Outcomes through Research for Newborns (BORN) Network
缺乏证据来指导围产期 SARS-CoV-2 感染妇女所生晚期早产儿和足月新生儿的临床护理。本病例系列的目的是描述美国医院的早期新生儿结局和住院患者管理。我们从新生儿研究更好的结果 (BORN) 网络成员那里收集了受 COVID-19 影响的母婴案例。使用结构化病例模板，参与站点提供了出生时妊娠 ≥ 35 周且母亲在分娩前 SARS-CoV-2 检测呈阳性的新生儿的去识别化、回顾性出生住院数据。我们描述人口统计学和临床特征、临床管理和新生儿结局。美国16家医院贡献了70例。 66 名 (94%) 新生儿的分娩住院治疗并不复杂； 4 例 (6%) 需要入住新生儿重症监护病房。没有人需要进行感染评估或治疗，所有接受 SARS-CoV-2 检测的人均为阴性 (n=57)。一半的二人住在一起（n = 34），40％的人直接母乳喂养（n = 28）。可获得 13 名新生儿的门诊随访数据，所有这些新生儿均无症状。在这个由 70 名感染 SARS-CoV-2 的妇女所生的新生儿组成的多中心病例系列中，临床结果总体良好，而且我们没有记录到新生儿 SARS-CoV-2 感染。临床管理在很大程度上与美国同期的 COVID-19 护理指南不一致，这表明人们对这些建议的可接受性和可行性表示担忧。迫切需要进行纵向研究来评估当前实践的利弊，为循证临床护理提供信息并帮助共同决策。
There is a paucity of evidence to guide the clinical care of late preterm and term neonates born to women with perinatal SARS-CoV-2 infection. The objective of this case series is to describe early neonatal outcomes and inpatient management in US hospitals. We solicited cases of mother-infant dyads affected by COVID-19 from Better Outcomes through Research for Newborns (BORN) Network members. Using a structured case template, participating sites contributed de-identified, retrospective birth hospitalization data for neonates ≥35 weeks of gestation at birth with mothers who tested positive for SARS-CoV-2 before delivery. We describe demographic and clinical characteristics, clinical management, and neonatal outcomes. Sixteen US hospitals contributed 70 cases. Birth hospitalizations were uncomplicated for 66 (94%) neonates; 4 (6%) required admission to a neonatal intensive care unit. None required evaluation or treatment for infection, and all who were tested for SARS-CoV-2 were negative (n=57). Half of the dyads were co-located (n=34), and 40% directly breastfed (n=28). Outpatient follow-up data were available for 13 neonates, all of whom remained asymptomatic. In this multi-site case series of 70 neonates born to women with SARS-CoV-2 infection, clinical outcomes were overall good, and there we no documented neonatal SARS-CoV-2 infections. Clinical management was largely inconsistent with contemporaneous US COVID-19 guidelines for nursery care, suggesting concerns about the acceptability and feasibility of those recommendations. Longitudinal studies are urgently needed to assess the benefits and harms of current practices to inform evidence-based clinical care and aid shared decision making.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
8
作者：
Perlman, Jeffrey;Oxford, Corrina;Di Pace, Jennifer
通讯作者：
Di Pace, Jennifer
影响因子：
168.9
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
通讯作者：
Zhang, Yuanzhen
影响因子：
2.5
作者：
Murray, Erin K.;Ricketts, Sue;Dellaport, Jennifer
通讯作者：
Dellaport, Jennifer
DOI：
10.1016/j.ajogmf.2020.100118
发表时间：
2020-05-01
影响因子：
6.3
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
通讯作者：
Goffman, Dena