A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery.
A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery.
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DOI：
10.1371/journal.pone.0108880
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Konofagou EE
中科院分区：
文献类型：
--
作者：
Chen H;Chen CC;Acosta C;Wu SY;Sun T;Konofagou EE
由于血脑屏障（BBB）阻止大多数药物进入大脑，中枢神经系统（CNS）疾病难以治疗。鼻内（IN）给药是绕过BBB向大脑递送药物的一种有前途的方法;然而，其应用仅限于特别有效的物质，并且不能向特定的大脑部位提供局部递送。聚焦超声（FUS）结合微泡可以将药物输送到大脑的目标位置。本研究提出将这两种不同的平台技术（FUS+IN）联合收割机用于增强鼻内给药药物在靶向位置的递送效率。在IN施用40 kDa荧光标记的葡聚糖作为模型药物后，在全身施用微泡的存在下应用靶向小鼠脑的尾壳核内的一个区域的FUS。为了与采用静脉内（IV）药物注射的常规FUS技术进行比较，在另一组小鼠中IV注射相同量的葡聚糖后也应用FUS。使用脑切片的荧光成像评价葡聚糖递送结果。结果表明，FUS+IN与IN相比，增强了靶向区域内的药物递送。尽管IN途径具有有限的药物通过鼻粘膜吸收的事实，但是FUS+IN的递送效率与FUS+IV的递送效率没有显著差异。FUS+IN技术作为一种新的药物传递平台，在治疗中枢神经系统疾病方面具有潜在的应用价值。
Central nervous system (CNS) diseases are difficult to treat because of the blood-brain barrier (BBB), which prevents most drugs from entering into the brain. Intranasal (IN) administration is a promising approach for drug delivery to the brain, bypassing the BBB; however, its application has been restricted to particularly potent substances and it does not offer localized delivery to specific brain sites. Focused ultrasound (FUS) in combination with microbubbles can deliver drugs to the brain at targeted locations. The present study proposed to combine these two different platform techniques (FUS+IN) for enhancing the delivery efficiency of intranasally administered drugs at a targeted location. After IN administration of 40 kDa fluorescently-labeled dextran as the model drug, FUS targeted at one region within the caudate putamen of mouse brains was applied in the presence of systemically administered microbubbles. To compare with the conventional FUS technique, in which intravenous (IV) drug injection is employed, FUS was also applied after IV injection of the same amount of dextran in another group of mice. Dextran delivery outcomes were evaluated using fluorescence imaging of brain slices. The results showed that FUS+IN enhanced drug delivery within the targeted region compared with that achieved by IN only. Despite the fact that the IN route has limited drug absorption across the nasal mucosa, the delivery efficiency of FUS+IN was not significantly different from that of FUS+IV. As a new drug delivery platform, the FUS+IN technique is potentially useful for treating CNS diseases.
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影响因子：
3.5
作者：
Baseri B;Choi JJ;Deffieux T;Samiotaki G;Tung YS;Olumolade O;Small SA;Morrison B;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
11.2
作者：
McDannold N;Arvanitis CD;Vykhodtseva N;Livingstone MS
通讯作者：
Livingstone MS
DOI：
10.1109/tbme.2009.2034533
发表时间：
2010-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Choi JJ;Feshitan JA;Baseri B;Wang S;Tung YS;Borden MA;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
3.7
作者：
Chapman, Colin D.;Frey, William H., II;Craft, Suzanne;Danielyan, Lusine;Hallschmid, Manfred;Schithoth, Helgi B.;Benedict, Christian
通讯作者：
Benedict, Christian
影响因子：
4.7
作者：
Lai CY;Fite BZ;Ferrara KW
通讯作者：
Ferrara KW