Intranasal treatment of central nervous system dysfunction in humans.
Intranasal treatment of central nervous system dysfunction in humans.
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DOI：
10.1007/s11095-012-0915-1
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发表时间：
2013-10
影响因子：
3.7
通讯作者：
Benedict, Christian
中科院分区：
文献类型：
--
作者：
Chapman, Colin D.;Frey, William H., II;Craft, Suzanne;Danielyan, Lusine;Hallschmid, Manfred;Schithoth, Helgi B.;Benedict, Christian
现代医学面临的最具挑战性的问题之一是如何在排除其他地区的情况下将一种给定的药物输送到特定的目标。例如，各种化合物在中枢神经系统(CNS)内有有益的作用，但在外周有不想要的副作用。对于这类化合物，传统的口服或静脉给药无法提供无成本的好处。然而，鼻腔给药正在成为一种非侵入性的选择，可以将药物输送到中枢神经系统，外周暴露最少。此外，这种方法便于输送无法有效穿越血脑屏障(BBB)的大剂量和/或带电治疗药物。因此，对于各种生长因子、激素、神经肽和包括胰岛素、催产素、食欲素甚至干细胞在内的治疗方法，鼻腔给药正在成为一种有效的给药方法，并代表着一种很有前途的治疗策略，可用于治疗与中枢神经系统有关的疾病，如肥胖、阿尔茨海默病、帕金森病、亨廷顿病、抑郁症、焦虑症、自闭症谱系障碍、癫痫、药物成瘾、饮食紊乱和中风。
One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but unwanted side effects in the periphery. For such compounds, traditional oral or intravenous drug delivery fails to provide benefit without cost. However, intranasal delivery is emerging as a noninvasive option for delivering drugs to the CNS with minimal peripheral exposure. Additionally, this method facilitates the delivery of large and/or charged therapeutics, which fail to effectively cross the blood-brain barrier (BBB). Thus, for a variety of growth factors, hormones, neuropeptides and therapeutics including insulin, oxytocin, orexin, and even stem cells, intranasal delivery is emerging as an efficient method of administration, and represents a promising therapeutic strategy for the treatment of diseases with CNS involvement, such as obesity, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, anxiety, autism spectrum disorders, seizures, drug addiction, eating disorders, and stroke.
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影响因子：
3.7
作者：
Benedict, C;Hallschmid, M;Kern, W
通讯作者：
Kern, W
影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
影响因子：
4.3
作者：
Chartoff EH;Damez-Werno D;Sonntag KC;Hassinger L;Kaufmann DE;Peterson J;McPhie D;Cataldo AM;Cohen BM
通讯作者：
Cohen BM
DOI：
10.1159/000321044
发表时间：
2011-01-01
期刊：
TOPICAL APPLICATIONS AND THE MUCOSA
影响因子：
--
作者：
Bitter, Christoph;Suter-Zimmermann, Katja;Surber, Christian
通讯作者：
Surber, Christian
影响因子：
2.9
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A