A longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine, evaluated by computed tomography: the Framingham Study.
A longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine, evaluated by computed tomography: the Framingham Study.
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DOI：
10.1016/j.spinee.2018.04.010
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Samelson EJ
中科院分区：
文献类型：
--
作者：
Jarraya M;Guermazi A;Lorbergs AL;Brochin E;Kiel DP;Bouxsein ML;Cupples LA;Samelson EJ
在非临床人群中，胸腰椎区域椎间盘高度狭窄（DHN）和小关节骨关节炎（FJOA）的患病率和进展情况尚未得到充分证实。使用计算机断层扫描（CT）图像根据年龄、性别和脊柱区域确定DHN和FJOA的患病率和进展。6年纵向研究Frachial研究的1，196名成员（平均基线年龄61 ±9岁）我们比较了年龄，性别和脊柱区域的中重度DHN和FJOA的患病率和进展（新发或恶化）。肌肉骨骼放射科医生使用半定量量表评价基线和随访CT图像上T4/T5至L4/L5的DHN和FJOA：0=正常，1=轻度，2=中度，3=重度。基线时年龄在40-59岁的女性和男性中，有三分之一或更多的人有基于图像的证据表明存在DHN，超过一半的人存在FJOA，基线时年龄在60-69岁和70-89岁的人中，DHN和FJOA的患病率分别增加约2至4倍; p<0.01）。DHN和FJOA的进展发生在腰椎比胸椎更常见，女性比男性更常见（DHN：OR=1.42，CI=1.07，1.88; FJOA：OR=1.70，CI=1.33，2.17）。中重度DHN和FJOA的患病率和进展在老年人的非临床人群中很常见。在这项以社区为基础的研究中，CT上观察到的脊柱退变频率很高，这可能会给解释DHN和FJOA影像学证据的临床意义带来挑战。未来的研究需要调查基于CT的脊柱退行性特征与基于人群的样本中疼痛和功能障碍的相关性，以帮助确定基于DHN和FJOA影像学结果的临床意义。
Prevalence and progression of disc height narrowing (DHN) and facet joint osteoarthritis (FJOA) in the thoracic and lumbar regions in non-clinical populations are not well-established. Use computed tomography (CT) images to determine prevalence and progression of DHN and FJOA according to age, sex, and spinal region. Six-year longitudinal study 1,196 members of the Framingham Study (mean baseline age 61 ±9 years) We compared prevalence and progression (new or worsening) of moderate-to-severe DHN and FJOA by age, sex, and spinal region. A musculoskeletal radiologist evaluated DHN and FJOA from T4/T5 to L4/L5 on baseline and follow-up CT images using a semi-quantitative scale as: 0=normal, 1=mild, 2=moderate, and 3=severe. One-third or more of women and men ages 40–59 years at baseline had imaged-based evidence of prevalent DHN, more than half had prevalent FJOA, and DHN and FJOA prevalence increased ~2- to 4-fold in those age 60–69 and 70–89 years at baseline, respectively; p<0.01). Progression of DHN and FJOA occurred more frequently at the lumbar than thoracic spine and more in women than men (DHN: OR=1.42, CI=1.07, 1.88; FJOA: OR=1.70, CI=1.33, 2.17). Prevalence and progression of moderate-to-severe DHN and FJOA are common in non-clinical populations of older adults. The high frequency of spinal degeneration observed on CTs in this community-based study may contribute to challenges in interpreting the clinical significance of imaging evidence of DHN and FJOA. Future studies investigating the association of CT based spinal degenerative features with pain and functional impairments in population-based samples are needed to help determine clinical significance of imaged based findings of DHN and FJOA.
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作者：
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作者：
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影响因子：
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作者：
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Jordan, Joanne M.
DOI：
10.3174/ajnr.a4173
发表时间：
2015-04
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Brinjikji W;Luetmer PH;Comstock B;Bresnahan BW;Chen LE;Deyo RA;Halabi S;Turner JA;Avins AL;James K;Wald JT;Kallmes DF;Jarvik JG
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