Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product
Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product
复制标题
人糖皮质激素受体的结构域结构及其与v-erb-A癌基因产物的关系
作者：
C. Weinberger;S. Hollenberg;M. Rosenfeld;R. Evans
类固醇与其核受体的相互作用诱导了一系列调节事件，这些事件是由激素/受体复合物激活特定基因组引起的1。类固醇单独作用或可能与其他生长因子协同作用，可以影响特定靶细胞的DNA合成和增殖，启动发育途径并激活分化表型的表达2 -7。此外，类固醇激素还与肿瘤和肿瘤衍生细胞系的异常生长调节有关8，9。编码人糖皮质激素受体（hGR）的互补DNA的鉴定预测了两种蛋白质形式（α和β;分别为777和742个氨基酸长），其羧基末端不同10。我们在这里报告，这两种形式的受体有关，就其结构域结构而言，v-erb-A癌基因产物的禽成红细胞增多症病毒（AEV），这表明类固醇受体基因和c-erb-A原癌基因是来自一个共同的原始调控基因。因此，AEV的致瘤性可能部分是由于截短的类固醇受体或由v-erb-A编码的相关调节分子的不适当活性。这表明了一种机制，通过这种机制，交易因素可能会促进转化。我们还确定了一个短的区域的hGR是同源的果蝇同源异形蛋白编码的cannapedia和fushi tarazu。
The interaction of steroids with their nuclear receptors induces a cascade of regulatory events that results from the activation of specific sets of genes by the hormone/receptor complex1. Steroids, either acting alone or possibly synergistically with other growth factors, can influence the DNA synthesis and proliferation of specific target cells, initiate developmental pathways and activate expression of the differentiated phenotype2–7. Moreover, steroid hormones have been implicated in abnormal growth regulation both in tumours and tumour-derived cell lines8,9. The identification of complementary DNAs encoding the human glucocorticoid receptor (hGR) predicts two protein forms (α and β; 777 and 742 amino acids long, respectively) which differ at their carboxy termini10. We report here that both forms of the receptor are related, with respect to their domain structure, to the v-erb-A oncogene product of avian erythroblastosis virus (AEV), which suggests that steroid receptor genes and the c-erb-A proto-oncogene are derived from a common primordial regulatory gene. Therefore, oncogenicity by AEV may result, in part, from the inappropriate activity of a truncated steroid receptor or a related regulatory molecule encoded by v-erb-A. This suggests a mechanism by which transacting factors may facilitate transformation. We also identify a short region of hGR that is homologous with the Drosophila homoeotic proteins encoded by Antennapedia and fushi tarazu.
影响因子：
56.9
作者：
SCHECHTER, AL;HUNG, MC;COUSSENS, L
通讯作者：
COUSSENS, L
DOI：
10.1073/pnas.81.13.4115
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SCOTT, MP;WEINER, AJ
通讯作者：
WEINER, AJ