Infections in early life and childhood leukaemia risk: a UK case-control study of general practitioner records.
Infections in early life and childhood leukaemia risk: a UK case-control study of general practitioner records.
复制标题
DOI：
10.1038/sj.bjc.6604696
复制
发表时间：
2008-11-04
影响因子：
8.8
通讯作者：
Murray LJ
中科院分区：
文献类型：
--
作者：
Cardwell CR;McKinney PA;Patterson CC;Murray LJ
我们在英国全科医学研究数据库（GPRD）中调查了早期感染（在全科医学中诊断）和随后的儿童白血病风险。所有在GPRD诊所出生并随后被诊断为白血病的儿童均被确定为病例，并与多达20名对照组进行单独匹配（出生年份、性别和诊所）。最终分析包括162例白血病病例和2215例匹配对照。条件Logistic回归分析显示，没有证据表明在出生后第一年内有一次或多次感染记录的儿童患白血病（OR=1.05，95%CI 0.69，1.59; P=0.83）或急性淋巴细胞白血病（ALL; OR=1.05，95%CI 0.64-1.74; P=0.84）的风险降低。我们的研究没有提供对Greaves假说的支持，Greaves假说提出，在早期生活中减少或延迟暴露于感染会增加儿童ALL的风险。
We investigated infections in early life (diagnosed in general practice) and subsequent risk of childhood leukaemia in the UK General Practice Research Database (GPRD). All children born at GPRD practices and subsequently diagnosed with leukaemia were identified as cases and were individually matched (on year of birth, sex and practice) to up to 20 controls. The final analysis included 162 leukaemia cases and 2215 matched controls. Conditional logistic regression demonstrated no evidence that children with one or more recorded infection in the first year of life had a reduced risk of leukaemia (OR=1.05, 95%CI 0.69, 1.59; P=0.83) or acute lymphoblastic leukaemia (ALL; OR=1.05, 95%CI 0.64–1.74; P=0.84). Our study provides no support for the Greaves hypothesis, which proposes that reduced or delayed exposure to infections in early life increases the risk of childhood ALL.
登录
查看更多内容
影响因子：
8.8
作者：
Sch端z, J;Kaletsch, U;Meinert, R;Kaatsch, P;Michaelis, J
通讯作者：
Michaelis, J
影响因子：
5
作者：
MacArthur, Amy C.;McBride, Mary L.;Theriault, Gilles P.
通讯作者：
Theriault, Gilles P.
DOI：
10.1093/oxfordjournals.pubmed.a042571
发表时间：
1991-02-01
期刊：
JOURNAL OF PUBLIC HEALTH MEDICINE
影响因子：
--
作者：
MCKINNEY, PA;ALEXANDER, FE;CARRETTE, J
通讯作者：
CARRETTE, J
影响因子：
8.8
作者：
Dockerty, JD;Skegg, DCG;Elwood, JM;Herbison, GP;Becroft, DMO;Lewis, ME
通讯作者：
Lewis, ME
影响因子：
3.8
作者：
Ma, XM;Buffler, PA;Wiencke, JK
通讯作者：
Wiencke, JK