Association of childhood leukaemia with factors related to the immune system.
Association of childhood leukaemia with factors related to the immune system.
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DOI：
10.1038/sj.bjc.6690395
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发表时间：
1999-05
影响因子：
8.8
通讯作者：
Michaelis, J
中科院分区：
文献类型：
--
作者：
Sch端z, J;Kaletsch, U;Meinert, R;Kaatsch, P;Michaelis, J
儿童期常见的急性淋巴细胞白血病高峰期被认为是对延迟暴露于常见感染的罕见反应。在这种情况下，与儿童免疫系统有关的因素特别令人感兴趣。关于这些因素的信息是在最近的一项德国病例对照研究中获得的，该研究包括1000多名急性白血病儿童。无论是头胎还是母乳喂养时间短，婴儿期病毒接触不足的指标或传染病的数量都不是重要的风险因素。我们观察到与常规免疫接种次数较少有很强的相关性，接种少于四次免疫接种的儿童的发病率增加了3.2倍，但这种相关性可以部分由报告偏见来解释。虽然扁桃体切除术或阑尾切除术在我们的研究中增加了患白血病的风险，但可以看到过敏的保护作用。总之，我们发现延迟暴露假说的支持率很低。在某种程度上，这可能是由于所选择的替代标志物反映了婴儿期的免疫隔离和延迟暴露于常见病毒。然而，常规免疫接种、扁桃体切除术和儿童或其父母过敏的重要发现值得进一步调查。© 1999癌症研究运动
The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child’s immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprising more than 1000 children with acute leukaemia. Neither being the first-born child, nor a short duration of breastfeeding, indicators of a deficit in viral contacts during infancy or the number of infectious diseases, were significant risk factors. We observed a strong association with fewer routine immunizations with a 3.2-fold increase for those children getting less than four immunizations, but this association could partly be explained by reporting bias. While tonsillectomy or appendectomy increased the risk of leukaemia in our studies, a protective effect of allergies could be seen. In summary, we found only weak support for the delayed exposure hypothesis. To some extent this may be due to the chosen surrogate markers which reflect, rather indirectly, immunological isolation in infancy and delayed exposure to common viruses. However, the significant findings for routine immunizations, tonsillectomy and allergies of the child or its parents merit further investigation. © 1999 Cancer Research Campaign
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影响因子：
168.9
作者：
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通讯作者：
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