Infections, vaccinations, and the risk of childhood leukaemia.
Infections, vaccinations, and the risk of childhood leukaemia.
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DOI：
10.1038/sj.bjc.6690548
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发表时间：
1999-07
影响因子：
8.8
通讯作者：
Lewis, ME
中科院分区：
文献类型：
--
作者：
Dockerty, JD;Skegg, DCG;Elwood, JM;Herbison, GP;Becroft, DMO;Lewis, ME
新西兰进行了一项全国性病例对照研究，以检验有关感染在儿童白血病病因学中的作用的假设。 0-14 岁患有白血病的儿童在年龄和性别上与从出生记录中选择的对照进行匹配。病例查明工作已基本完成，131 个符合条件的病例家庭中有 121 个（92%）参与了调查。 303名首选合格对照的参与率为69%。进行了家庭访谈和血清学检测。通过逻辑回归估计调整后的相对风险。儿童在出生第一年报告的流感感染会增加患白血病的风险（调整后的比值比为 6.8，95% 置信区间为 1.8-25.7）。这可能是多次比较的偶然发现，应该在其他地方进行测试。与格里夫斯的假设相关的一些关键变量与 B 细胞前体急性淋巴细胞白血病无关（感染和疫苗接种的数量、第一胎状况、学前班入学率），尽管如此规模的研究不能排除小的影响。社会环境较差的儿童患白血病的风险较高，所有符合条件的儿童以及参与者都是如此。 © 1999 癌症研究运动
A nationwide case-control study was conducted in New Zealand, to test hypotheses about the role of infections in the aetiology of childhood leukaemia. Children aged 0–14 years with leukaemia were matched on age and sex to controls selected from birth records. Case ascertainment was virtually complete and 121 (92%) of 131 eligible case families took part. The participation rate among the 303 first-choice eligible controls was 69%. Home interviews and serological tests were conducted. Adjusted relative risks were estimated by logistic regression. There was an increased risk of leukaemia in relation to reported influenza infection of the child during the first year of life (adjusted odds ratio 6.8, 95% confidence interval 1.8–25.7). This could be a chance finding due to multiple comparisons, and it should be tested elsewhere. Some key variables relevant to Greaves' hypothesis were not associated with B-cell precursor acute lymphoblastic leukaemia (numbers of infections and vaccinations, firstborn status, attendance at preschool groups), although a small effect could not be ruled out with a study of this size. Leukaemia risk was higher among children in poorer social circumstances, and this was true for all eligible children as well as for the participants. © 1999 Cancer Research Campaign
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影响因子：
--
作者：
BITHELL, JF;DRAPER, GJ;GORBACH, PD
通讯作者：
GORBACH, PD
DOI：
10.1177/146642409611600608
发表时间：
1996-12-01
期刊：
JOURNAL OF THE ROYAL SOCIETY OF HEALTH
影响因子：
--
作者：
Kinlen, LJ
通讯作者：
Kinlen, LJ
影响因子：
8.8
作者：
Kinlen, LJ
通讯作者：
Kinlen, LJ
影响因子：
2.3
作者：
Dockerty, JD;Elwood, JM;Herbison, GP
通讯作者：
Herbison, GP
影响因子：
7.2
作者：
HAMAJIMA, N;HIROSE, K;TAJIMA, K
通讯作者：
TAJIMA, K