Applying Principles of Regenerative Medicine to Vascular Stent Development.
Applying Principles of Regenerative Medicine to Vascular Stent Development.
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DOI：
10.3389/fbioe.2022.826807
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发表时间：
2022
影响因子：
5.7
通讯作者：
Tan W
中科院分区：
文献类型：
--
作者：
Selvakumar PP;Rafuse MS;Johnson R;Tan W
支架是一种广泛使用的治疗各种心血管疾病的装置。本综述的目的是探讨再生医学原理在当前和未来支架设计中的应用。本综述将包括目前支架技术研究领域中出现的与再生相关的方法。再生支架技术包括具有细胞分泌体的支架表面工程、细胞捕获涂层、内皮产品的模拟、表面形貌、内皮生长因子或细胞粘附肽，以及用于临时支架支架的生物可吸收材料的设计。对这些技术的再生效果、治疗效果和面临的挑战进行了比较分析，权衡了它们的优点和风险，为未来支架的发展提供了建议。本文重点介绍了支架技术的两个独特的再生特征：选择性再生，即选择性地在支架上种植内皮细胞，但抑制血管内皮细胞的增殖和迁移；支架辅助的缺血组织损伤再生。
Stents are a widely-used device to treat a variety of cardiovascular diseases. The purpose of this review is to explore the application of regenerative medicine principles into current and future stent designs. This review will cover regeneration-relevant approaches emerging in the current research landscape of stent technology. Regenerative stent technologies include surface engineering of stents with cell secretomes, cell-capture coatings, mimics of endothelial products, surface topography, endothelial growth factors or cell-adhesive peptides, as well as design of bioresorable materials for temporary stent support. These technologies are comparatively analyzed in terms of their regenerative effects, therapeutic effects and challenges faced; their benefits and risks are weighed up for suggestions about future stent developments. This review highlights two unique regenerative features of stent technologies: selective regeneration, which is to selectively grow endothelial cells on a stent but inhibit the proliferation and migration of smooth muscle cells, and stent-assisted regeneration of ischemic tissue injury.
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