Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.
Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.
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DOI：
10.1038/s41556-021-00676-z
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发表时间：
2021-05
影响因子：
21.3
通讯作者：
Cordero JB
中科院分区：
文献类型：
--
作者：
Perochon J;Yu Y;Aughey GN;Medina AB;Southall TD;Cordero JB
局部和生态位衍生信号对干细胞功能的协调对于维持成体组织稳态和有机体健康至关重要。脉管系统是多个干细胞生态位的重要组成部分。然而，它在成人肠道稳态中的作用仍然没有得到充分研究。在这里，我们发现了果蝇中成体肠道干细胞（ISC）和类脉管系统气管系统之间以前未被识别的串扰，这对于肠道再生至关重要。肠上皮损伤后，肠源性活性氧 (ROS) 激活气管 HIF-1α 和双向 FGF/FGFR 信号传导，导致损伤后肠道相关末端气管细胞的可逆重塑和 ISC 增殖。出乎意料的是，ROS诱导的成人气管可塑性涉及气管规范因子trachealess (trh)的下调和IGF2 mRNA结合蛋白(IGF2BP2/Imp)的上调。我们的结果揭示了肠道/脉管系统器官间通讯程序，这对于调整干细胞对肠上皮增殖需求的反应至关重要。
Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here, we uncover a previously unrecognised crosstalk between adult intestinal stem cells (ISCs) in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration. Following damage to the intestinal epithelium, gut-derived reactive oxygen species (ROS) activate tracheal HIF-1α and bidirectional FGF/FGFR signalling, leading to reversible remodelling of gut-associated terminal tracheal cells and ISC proliferation following damage. Unexpectedly, ROS-induced adult tracheal plasticity involves downregulation of the tracheal specification factor trachealess (trh) and upregulation of IGF2 mRNA-binding protein (IGF2BP2/Imp). Our results reveal an intestine/vasculature inter-organ communication programme, which is essential to adapt stem cells response to the proliferative demands of the intestinal epithelium.
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影响因子：
11.4
作者：
Cordero, Julia B.;Stefanatos, Rhoda K.;Scopelliti, Alessandro;Vidal, Marcos;Sansom, Owen J.
通讯作者：
Sansom, Owen J.
影响因子：
11.8
作者：
Holloway, Emily M.;Wu, Joshua H.;Spence, Jason R.
通讯作者：
Spence, Jason R.
影响因子：
7.5
作者：
Eilken, Hanna M.;Adams, Ralf H.
通讯作者：
Adams, Ralf H.
影响因子：
11.8
作者：
Ha, EM;Oh, CT;Lee, WJ
通讯作者：
Lee, WJ
影响因子：
2.2
作者：
Centanin, Lazaro;Gorr, Thomas A.;Wappner, Pablo
通讯作者：
Wappner, Pablo