Cerebral blood flow measured with diffusing wave spectroscopy during anesthesia

Cerebral blood flow measured with diffusing wave spectroscopy during anesthesia
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麻醉期间用扩散波谱测量脑血流量

DOI:
10.1101/438028
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发表时间:
--
期刊:
bioRxiv
影响因子:
--
通讯作者:
Georg Maret
Georg Maret
中科院分区:
--
文献类型:
--
作者:
Markus Belau;Wolfgang Scheffer;Georg Maret

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大脑的充分灌注是至关重要的,其中已经短时间的灌注不足可能导致永久性损伤。为了提高患者的安全性,应在临床环境中监测灌注可能受到干扰的情况下(例如麻醉)的脑血流。然而,在麻醉过程中,脑血流量并没有被常规监测。扩散波谱学是一种相对新颖的光学方法,可以无创地测量脑血流的变化。在这里,我们报告的变化与延迟心输出量,异氟烷浓度和体温的变化,在鸽子异氟烷全身麻醉期间观察到的脑血流。
The adequate perfusion of the brain is of utmost importance where already short periods of hypoperfusion may lead to permanent damage. In order to increase patient safety the cerebral blood flow should be monitored in clinical settings during situations, such as anesthesia, where the perfusion might be disturbed. The cerebral blood flow is however not monitored on a routine basis during anesthesia. Diffusing wave spectroscopy is a relative novel optical method that non-invasively measures changes in cerebral blood flow. Here we report changes in cerebral blood flow associated with a delayed cardiac output, a change in isoflurane concentration and body temperature observed during general anesthesia with isoflurane in pigeons.
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