An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.
An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.
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DOI：
10.1038/s41598-022-14346-z
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发表时间：
2022-06-15
影响因子：
4.6
通讯作者：
Deng, Wenbin
中科院分区：
文献类型：
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作者：
Yang, Mengjie;Liu, Shuna;Xiong, Yue;Zhao, Jingxin;Deng, Wenbin
近年来，一些研究表明，线粒体肌酸激酶1A （CKMT1A）在各种癌症类型中起着关键作用。然而，对于CKMT1A在不同类型癌症中的作用仍然缺乏系统的了解。因此，本研究旨在探讨CKMT1A在人类肿瘤中的潜在作用。首先，我们评估了CKMT1A在33种肿瘤中的表达水平。其次，我们使用GEPIA2和Kaplan-Meier绘图仪来探索CKMT1A表达与生存预后的关系。此外，CKMT1A基因的遗传改变也通过基因门户网站进行了分析。此外，我们还进行了免疫浸润分析和基因富集途径分析。CKMT1A在大多数类型的癌症中高表达，CKMT1A的表达与某些肿瘤患者的预后有显著相关性。CKMT1A改变的非小细胞肺癌患者总体生存率较差。在大多数肿瘤中，CKMT1A的表达与癌相关成纤维细胞的浸润呈负相关。我们还发现，在一些肿瘤中，其表达与CD8+ t细胞浸润呈负相关。此外，富集分析表明CKMT1A的功能机制涉及“糖酵解/糖异生”和“代谢途径”功能。综上所述，我们的研究将为CKMT1A在不同肿瘤中的作用提供相对清晰和综合的理解。这些发现将为CKMT1A在肿瘤发生中的进一步分子分析奠定坚实的基础，并为开发新的治疗策略提供理论依据。
In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various cancer types. However, there is still a lack of systematic understanding of the contribution of CKMT1A in different types of cancer. Therefore, this study aims to explore the potential role of CKMT1A in human tumors. Firstly, we evaluated the expression level of CKMT1A in 33 types of tumors. Secondly, we used the GEPIA2 and Kaplan–Meier plotter to explore the relationship between CKMT1A expression and survival prognosis. Furthermore, the genetic alterations of CKMT1A were analyzed by the cBioPortal web. In addition, we performed immune infiltration analysis and gene enrichment pathway analysis. CKMT1A was highly expressed in most types of cancers and there was a significant correlation between CKMT1A expression and the prognosis of patients for certain tumors. Non-Small Cell Lung Cancer cases with altered CKMT1A showed a poorer overall survival. CKMT1A expression was negatively correlated with the infiltration of cancer-associated fibroblasts in most tumors. We also found that its expression was negatively associated with CD8+ T-cell infiltration in several tumors. Furthermore, enrichment analysis revealed that “Glycolysis/ Gluconeogenesis” and “metabolic pathways” functions were involved in the functional mechanism of CKMT1A. Taken together, our studies will provide a relatively clear and integrative understanding of the role of CKMT1A across different tumors. All these findings will lay a solid foundation for further molecular assays of CKMT1A in tumorigenesis and provide the rationale for developing novel therapeutic strategies.
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影响因子：
14.9
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