Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla.
Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla.
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DOI：
10.1016/j.cub.2021.10.030
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发表时间：
2022-01-10
期刊：
影响因子：
--
通讯作者：
Weber F
中科院分区：
文献类型：
--
作者：
Stucynski JA;Schott AL;Baik J;Chung S;Weber F
哺乳动物睡眠的两个主要阶段--快速眼动睡眠（REM）和非快速眼动睡眠（NREM）--的特征是不同的脑节律，范围从毫秒到分钟（次声）振荡。控制睡眠阶段之间转换的机制以及它们如何与次声节律同步仍然知之甚少。在小鼠中使用光学和化学操作，我们表明，GABA能神经元的背内侧髓质（dmM）促进启动和维持REM，部分通过其预测的背侧和正中中缝核。纤维光度测定显示，他们的活动强烈增加，在快速眼动和波动在NREM密切同步睡眠纺锤波带的脑电图中的次声振荡。该节律的相位影响dmM激活诱导REM的潜伏期和概率。因此，dmM抑制性神经元强烈地促进REM，并且它们的缓慢活动波动可以协调REM发作的时间与低脑节律。
The two major stages of mammalian sleep – rapid eye movement sleep (REMs) and non-REM sleep (NREMs) – are characterized by distinct brain rhythms ranging from millisecond to minute-long (infraslow) oscillations. The mechanisms controlling transitions between sleep stages and how they are synchronized with infraslow rhythms remain poorly understood. Using opto- and chemogenetic manipulation in mice, we show that GABAergic neurons in the dorsomedial medulla (dmM) promote the initiation and maintenance of REMs, in part through their projections to the dorsal and median raphe nuclei. Fiber photometry revealed that their activity is strongly increased during REMs and fluctuates during NREMs in close synchrony with infraslow oscillations in the sleep spindle band of the electroencephalogram. The phase of this rhythm influenced the latency and probability with which dmM activation induced REMs. Thus, dmM inhibitory neurons strongly promote REMs, and their slow activity fluctuations may coordinate the timing of REMs episodes with infraslow brain rhythms.
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