Plastic changes in primate motor cortex following paired peripheral nerve stimulation.
Plastic changes in primate motor cortex following paired peripheral nerve stimulation.
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DOI：
10.1152/jn.00288.2020
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发表时间：
2021-02-01
影响因子：
2.5
通讯作者：
Baker SN
中科院分区：
文献类型：
--
作者：
Habekost B;Germann M;Baker SN
重复成对刺激两个周围神经可以产生持久的变化，运动皮层兴奋性，但鲜为人知的是，潜在的神经元基础。在这里，我们训练两只猕猴进行选择性的拇指和食指外展运动。神经活动记录从对侧的初级运动皮层在任务的性能，刺激后的尺神经和正中神经，和神经供应伸趾总肌（EDC）肌肉。反应进行了比较之前和之后1小时的同步或异步配对尺/正中神经刺激。任务绩效显着增强后异步和受损后同步刺激。短潜伏期神经反应的幅度增加后，异步刺激正中神经和尺神经刺激;后成分减少后，同步刺激。同步刺激增加拇指运动过程中的神经活动，减少食指运动过程中的神经活动;异步刺激减少两种运动过程中的活动。为了评估神经活动如何区分行为或感觉条件，线性判别分析被用来解码哪个神经受到刺激，或者哪个手指移动。神经刺激的解码准确性在同步配对刺激后降低，在异步配对刺激后增加。解码准确性的任务表现后，同步下降，但异步配对刺激后不变。配对刺激产生的变化，运动皮层电路，持续时间超过刺激。其中一些变化取决于精确的刺激时机。新&值得注意的是，配对刺激外周神经1小时诱导运动皮层内对神经刺激和行为任务的表现的神经反应的持久变化。这些变化足以改变活动编码刺激类型的效率。可以很容易地非侵入性地应用于人类受试者的刺激可以改变中枢运动回路。
Repeated paired stimulation of two peripheral nerves can produce lasting changes in motor cortical excitability, but little is known of the underlying neuronal basis. Here, we trained two macaque monkeys to perform selective thumb and index finger abduction movements. Neural activity was recorded from the contralateral primary motor cortex during task performance, and following stimulation of the ulnar and median nerves, and the nerve supplying the extensor digitorum communis (EDC) muscle. Responses were compared before and after 1 h of synchronous or asynchronous paired ulnar/median nerve stimulation. Task performance was significantly enhanced after asynchronous and impaired after synchronous stimulation. The amplitude of short latency neural responses to median and ulnar nerve stimulation was increased after asynchronous stimulation; later components were reduced after synchronous stimulation. Synchronous stimulation increased neural activity during thumb movement and decreased it during index finger movement; asynchronous stimulation decreased activity during both movements. To assess how well neural activity could separate behavioral or sensory conditions, linear discriminant analysis was used to decode which nerve was stimulated, or which digit moved. Decoding accuracy for nerve stimulation was decreased after synchronous and increased after asynchronous paired stimulation. Decoding accuracy for task performance was decreased after synchronous but was unchanged after asynchronous paired stimulation. Paired stimulation produces changes in motor cortical circuits that outlast the stimulation. Some of these changes depend on precise stimulus timing. NEW & NOTEWORTHY Paired stimulation of peripheral nerves for 1 h induced lasting changes in neural responses within the motor cortex to nerve stimulation and to performance of a behavioral task. These changes were sufficient to alter the efficiency with which activity could encode stimulus type. Stimuli that can be easily applied noninvasively in human subjects can alter central motor circuits.
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人类运动皮质输出的塑性变化是由随机但不是闭环外围刺激引起的：因果关系的诅咒。
影响因子：
2.9
作者：
Brown KI;Williams ER;de Carvalho F;Baker SN
通讯作者：
Baker SN
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JONES, EG;COULTER, JD;HENDRY, SHC
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HENDRY, SHC
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3
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Baker, SN;Philbin, N;Lemon, RN
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Lemon, RN
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COPE, TC;FETZ, EE;MATSUMURA, M
通讯作者：
MATSUMURA, M
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4.2
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Choudhury S;Singh R;Shobhana A;Sen D;Anand SS;Shubham S;Gangopadhyay S;Baker MR;Kumar H;Baker SN
通讯作者：
Baker SN