Preconception ovarian reserve and placenta-mediated pregnancy complications among infertile women.
Preconception ovarian reserve and placenta-mediated pregnancy complications among infertile women.
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不育妇女的卵巢储备和胎盘介导的妊娠并发症。
DOI：
10.1016/j.preghy.2022.01.010
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
NIH/NICHD Reproductive Medicine Network
中科院分区：
文献类型：
--
作者：
Vitek W;Oh J;Mbowe O;Thurston SW;Christianson MS;Styer AK;Polotsky AJ;Diamond MP;Cedars MI;NIH/NICHD Reproductive Medicine Network
妊娠前卵巢储备标志物（例如抗苗勒管激素和窦卵泡计数）是否与超排卵妊娠的不明原因不孕女性的先兆子痫和胎盘介导的妊娠并发症相关？这是对患有不明原因不孕症的妇女进行的二次分析，这些妇女在参加卵巢刺激后多次宫内妊娠分析 (AMIGOS) 试验后获得单胎活产，随机将夫妇随机分配到使用来曲唑、克罗米芬或促性腺激素进行超排卵，并进行长达 4 个周期的授精。与对照组 (N=156) 相比，发生先兆子痫的妇女 (N=17) 的死亡率较低抗苗勒氏管激素水平（2.24±1.20 vs. 2.89±2.32，p=0.07）和较低的窦卵泡计数（18±7.67 vs. 21±11.43，p=0.16）；尽管这些差异在统计上并不显着。抗苗勒管激素（OR：1.00，95% CI：0.76–1.25）或窦卵泡计数（OR：0.98，95% CI：0.93–1.04）与先兆子痫之间以及抗苗勒管激素（OR：1.00，95% CI：0.83–1.17）与窦卵泡之间没有关系。调整年龄、BMI 和种族后，卵泡计数（OR：1.00，95% CI：0.97-1.04）与胎盘药物妊娠并发症的关系。对于因人工授精超数排卵而怀孕的不明原因不孕妇女，孕前卵巢储备标志物与先兆子痫和胎盘介导的妊娠并发症无关。
Are preconception ovarian reserve markers, such as Anti-Mullerian hormone and antral follicle count, associated with preeclampsia and placenta mediated pregnancy complications among women with unexplained infertility who conceive with superovulation? This is a secondary analysis of women with unexplained infertility who had a singleton live birth after enrollment in the Analysis of Multiple Intrauterine Gestations after Ovarian Stimulation (AMIGOS) trial that randomized couples to superovulation with letrozole, clomiphene, or gonadotropins with insemination for up to 4 cycles Compared to controls (N=156), women who developed preeclampsia (N=17) had lower Anti-Mullerian hormone levels (2.24±1.20 vs. 2.89±2.32, p=0.07) and lower antral follicle count (18±7.67 vs. 21±11.43, p=0.16); though these differences were not statistically significant. There was no relationship between Anti-Mullerian hormone (OR: 1.00, 95% CI: 0.76–1.25) or antral follicle count (OR: 0.98, 95% CI 0.93–1.04) with preeclampsia and between Anti-Mullerian hormone (OR: 1.00, 95% CI: 0.83–1.17) and antral follicle count (OR: 1.00, 95% CI: 0.97–1.04) with placenta medicated pregnancy complications after adjusting for age, BMI and race. Preconception ovarian reserve markers are not associated with preeclampsia and placenta mediated pregnancy complications among women with unexplained infertility who conceive with superovulation with insemination.
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影响因子：
6.7
作者：
Keegan, Debbra A.;Krey, Lewis C.;Noyes, Nicole
通讯作者：
Noyes, Nicole
DOI：
10.1111/ajo.12183
发表时间：
2014-06-01
影响因子：
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作者：
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通讯作者：
National Institute of Child Health and Human Development (NICHD) Reproductive Medicine Network
影响因子：
39.2
作者：
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通讯作者：
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影响因子：
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作者：
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