Engineered Extracellular Vesicles: Tailored-Made Nanomaterials for Medical Applications.
Engineered Extracellular Vesicles: Tailored-Made Nanomaterials for Medical Applications.
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DOI：
10.3390/nano10091838
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发表时间：
2020-09-15
期刊：
影响因子：
--
通讯作者：
Cox SC
中科院分区：
文献类型：
--
作者：
Man K;Brunet MY;Jones MC;Cox SC
细胞外囊泡（EVs）由于其作为细胞间通讯介质、调节组织发育和体内平衡的内在作用，正在成为有前景的纳米级治疗药物。由于ev的低免疫原性和天然的细胞靶向能力，人们对其作为组织再生或病理诊断的新型脱细胞工具的潜力进行了广泛的研究。然而，电动汽车的临床应用一直受到产量和异质性问题的阻碍。从亲代细胞和天然囊泡的修饰到人工仿生纳米颗粒的开发或生物材料的功能化，许多技术已被用于增强ev的治疗效果。本文将探讨各种工程策略，以提高电动汽车的可扩展性和治疗效果。在此，我们重点介绍了当前最先进的电动汽车工程技术，并讨论了每种技术的机遇和障碍。这被综合成一份指南，用于选择合适的策略，以最大限度地发挥ev作为纳米级治疗方法的潜在功效。
Extracellular vesicles (EVs) are emerging as promising nanoscale therapeutics due to their intrinsic role as mediators of intercellular communication, regulating tissue development and homeostasis. The low immunogenicity and natural cell-targeting capabilities of EVs has led to extensive research investigating their potential as novel acellular tools for tissue regeneration or for the diagnosis of pathological conditions. However, the clinical use of EVs has been hindered by issues with yield and heterogeneity. From the modification of parental cells and naturally-derived vesicles to the development of artificial biomimetic nanoparticles or the functionalisation of biomaterials, a multitude of techniques have been employed to augment EVs therapeutic efficacy. This review will explore various engineering strategies that could promote EVs scalability and therapeutic effectiveness beyond their native utility. Herein, we highlight the current state-of-the-art EV-engineering techniques with discussion of opportunities and obstacles for each. This is synthesised into a guide for selecting a suitable strategy to maximise the potential efficacy of EVs as nanoscale therapeutics.
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影响因子：
5.4
作者：
Deregibus MC;Figliolini F;D'Antico S;Manzini PM;Pasquino C;De Lena M;Tetta C;Brizzi MF;Camussi G
通讯作者：
Camussi G
影响因子：
7.5
作者：
Ader, Marius;Tanaka, Elly M.
通讯作者：
Tanaka, Elly M.
源自人间充质干细胞的治疗微泡的有效可扩展产生。
影响因子：
4.6
作者：
Cha JM;Shin EK;Sung JH;Moon GJ;Kim EH;Cho YH;Park HD;Bae H;Kim J;Bang OY
通讯作者：
Bang OY
影响因子：
5.4
作者：
Antimisiaris SG;Mourtas S;Marazioti A
通讯作者：
Marazioti A
影响因子：
12.4
作者：
Biscans, Annabelle;Haraszti, Reka A.;Khvorova, Anastasia
通讯作者：
Khvorova, Anastasia