Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery.

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery.
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DOI:
10.3390/pharmaceutics10040218
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发表时间:
2018-11-06
期刊:
影响因子:
5.4
通讯作者:
Marazioti A
Marazioti A
中科院分区:
医学2区
文献类型:
--
作者:
Antimisiaris SG;Mourtas S;Marazioti A

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外泌体和脂质体之间的相似性,以及几种类型的外泌体的高度亲器官性,最近促使了工程化外泌体或外泌体模拟物的开发,其可以是人工(脂质体)或细胞衍生的囊泡,作为靶向药物递送的先进平台。在这里,我们提供了使用外泌体或外泌体激发的系统用于药物递送的当前最新技术水平。我们回顾了各种方法的研究和每种方法的缺点。最后总结了迄今为止在这一领域所面临的挑战。
The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.
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