Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents.
Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents.
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DOI：
10.3945/jn.114.208397
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Lawlor DA
中科院分区：
文献类型：
--
作者：
Anderson EL;Howe LD;Fraser A;Macdonald-Wallis C;Callaway MP;Sattar N;Day C;Tilling K;Lawlor DA
背景：肥胖是非酒精性脂肪性肝病（NAFLD）的重要危险因素。因此，饮食摄入很可能与疾病的发展有关。目前缺乏评估儿童饮食摄入与NAFLD风险之间关系的前瞻性研究。目的：本研究旨在探讨能量、碳水化合物、糖、淀粉、蛋白质、单不饱和脂肪、多不饱和脂肪、饱和脂肪和总脂肪摄入量在3岁、7岁和13岁的青少年（平均年龄：17.8岁）和随后（平均年龄：17.8岁）超声扫描（USS）测量肝脏脂肪和硬度以及血清丙氨酸转氨酶、天冬氨酸转氨酶和γ-谷氨酰转移酶之间的关系。我们评估了在结果评估时观察到的关联是否通过脂肪量介导。方法：参与者来自雅芳父母与儿童纵向研究。用线性样条多水平模型计算了3 ~ 13岁儿童能量和常量营养素摄入量的变化轨迹。线性和逻辑回归模型检验了3岁、7岁和13岁时的能量摄入、绝对和能量调节的大量营养素摄入是否与肝脏预后相关。结果：所有年龄段的能量摄入与肝脏预后呈正相关；例如，在3岁时，每增加100千卡的能量摄入，美国肝脏脂肪测量的几率为1.79 （95% CI: 1.14, 2.79）。绝对宏量营养素摄入量与肝脏预后之间的关联不一致，并且在调整总能量摄入后减弱为零。在评估肝脏预后时，对脂肪量进行调整后，大多数关联减弱为零。结论：儿童和青少年早期能量摄入高与NAFLD风险高相关，而能量摄入来源的常量营养素的重要性较低。在结果评估时，这些关联似乎至少部分是由脂肪量介导的。
Background: Greater adiposity is an important risk factor for nonalcoholic fatty liver disease (NAFLD). Thus, it is likely that dietary intake is involved in the development of the disease. Prospective studies assessing the relation between childhood dietary intake and risk of NAFLD are lacking. Objective: This study was designed to explore associations between energy, carbohydrate, sugar, starch, protein, monounsaturated fat, polyunsaturated fat, saturated fat, and total fat intake by youth at ages 3, 7, and 13 y and subsequent (mean age: 17.8 y) ultrasound scan (USS)–measured liver fat and stiffness and serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase. We assessed whether observed associations were mediated through fat mass at the time of outcome assessment. Methods: Participants were from the Avon Longitudinal Study of Parents and Children. Trajectories of energy and macronutrient intake from ages 3–13 y were obtained with linear-spline multilevel models. Linear and logistic regression models examined whether energy intake and absolute and energy-adjusted macronutrient intake at ages 3, 7, and 13 y were associated with liver outcomes. Results: Energy intake at all ages was positively associated with liver outcomes; for example, the odds of having a USS-measured liver fat per 100 kcal increase in energy intake at age 3 y were 1.79 (95% CI: 1.14, 2.79). Associations between absolute macronutrient intake and liver outcomes were inconsistent and attenuated to the null after adjustment for total energy intake. The majority of associations attenuated to the null after adjustment for fat mass at the time liver outcomes were assessed. Conclusion: Higher childhood and early adolescent energy intake is associated with greater NAFLD risk, and the macronutrients from which energy intake is derived are less important. These associations appear to be mediated, at least in part, by fat mass at the time of outcome assessment.
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DOI：
10.1097/mpg.0b013e318229da1a
发表时间：
2012-01
影响因子：
2.9
作者：
Vos MB;Colvin R;Belt P;Molleston JP;Murray KF;Rosenthal P;Schwimmer JB;Tonascia J;Unalp A;Lavine JE;NASH CRN Research Group
通讯作者：
NASH CRN Research Group
影响因子：
4.7
作者：
Mager, D. R.;Patterson, C.;Roberts, E. A.
通讯作者：
Roberts, E. A.
影响因子：
5.4
作者：
Papandreou, Dimitrios;Karabouta, Zaharoula;Rousso, Israel
通讯作者：
Rousso, Israel
非酒精性脂肪肝病的发病机理。
DOI：
10.1093/qjmed/hcp158
发表时间：
2010-02
期刊：
QJM : monthly journal of the Association of Physicians
影响因子：
--
作者：
Dowman JK;Tomlinson JW;Newsome PN
通讯作者：
Newsome PN
影响因子：
5.4
作者：
Anderson, Emma L.;Tilling, Kate;Howe, Laura D.
通讯作者：
Howe, Laura D.