Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.
Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder.
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DOI：
10.1007/s11682-021-00552-2
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发表时间：
2022-04
影响因子：
3.2
通讯作者：
Magnotta VA
中科院分区：
文献类型：
--
作者：
Shaffer JJ Jr;Willour V;Fiedorowicz JG;Christensen GE;Long JD;Johnson CP;Schmitz SL;Williams AJ;Wemmie J;Magnotta VA
尽管自杀的风险很高，但相对较少的研究探讨了双相情感障碍中自杀和脑成像测量之间的关系。此外，很少有研究探讨大脑代谢改变可能与自杀企图有关的可能性。为了开始填补这些空白，我们评估了双相情感障碍参与者与自杀企图相关的功能（基于任务的fMRI）和代谢（定量T1ρ）差异。39名患有双相情感障碍的参与者在闪烁棋盘任务期间接受了fMRI，27名还接受了定量T1ρ。神经影像学和自杀企图史之间的关系进行了测试，同时调整年龄，性别和当前的情绪状态。使用校正的赤池信息标准量化两种自杀企图测量（二元：是/否和连续：尝试次数）之间的差异。曾试图自杀的参与者在视觉区和小脑有更大的功能磁共振成像任务相关激活。自杀企图的数量与杏仁核、前额皮质和小脑的BOLD反应差异有关。T1ρ定量增加与边缘系统、基底神经节和前额皮质区域的自杀企图数量相关。本研究是一项中等样本量的二次分析。自杀史测量之间的差异可能是由于统计功效的差异。自杀史与边缘系统、前额叶和小脑改变有关。比较有自杀企图和没有自杀企图的人的结果与使用自杀企图数量的结果不同，这表明这些变量具有不同的神经生物学基础。
Despite the high risk for suicide, relatively few studies have explored the relationship between suicide and brain imaging measures in bipolar disorder. In addition, fewer studies have explored the possibility that altered brain metabolism may be associated with suicide attempt. To begin to fill in these gaps, we evaluated functional (task based fMRI) and metabolic (quantitative T1ρ) differences associated with suicide attempt in participants with bipolar disorder. Thirty-nine participants with bipolar disorder underwent fMRI during a flashing checkerboard task and 27 also underwent quantitative T1ρ. The relationship between neuroimaging and history of suicide attempt was tested using multiple regression while adjusting for age, sex, and current mood state. Differences between two measures of suicide attempt (binary: yes/no and continuous: number of attempts) were quantified using the corrected Akaike Information Criterion. Participants who had attempted suicide had greater fMRI task-related activation in visual areas and the cerebellum. The number of suicide attempts was associated with a difference in BOLD response in the amygdala, prefrontal cortex, and cerebellum. Increased quantitative T1ρ was associated with number of suicide attempts in limbic, basal ganglia, and prefrontal cortex regions. This study is a secondary analysis with a modest sample size. Differences between measures of suicide history may be due to differences in statistical power. History of suicide was associated with limbic, prefrontal, and cerebellar alterations. Results comparing those with and without suicide attempts differed from results using number of suicide attempts, suggesting that these variables have different neurobiological underpinnings.
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躁郁症情绪状态中小脑和基底神经节的改变，通过定量T1ρ映射检测到。
影响因子：
5.4
作者：
Johnson CP;Christensen GE;Fiedorowicz JG;Mani M;Shaffer JJ Jr;Magnotta VA;Wemmie JA
通讯作者：
Wemmie JA
影响因子：
5.3
作者：
Baca-García, E;Oquendo, MA;de Leon, J
通讯作者：
de Leon, J
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC
影响因子：
3.3
作者：
Kettunen, MI;Gröhn, OHJ;Kauppinen, RA
通讯作者：
Kauppinen, RA
影响因子：
11
作者：
Johnson, C P;Follmer, R L;Wemmie, J A
通讯作者：
Wemmie, J A