Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.
Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.
复制标题
躁郁症情绪状态中小脑和基底神经节的改变，通过定量T1ρ映射检测到。
DOI：
10.1111/bdi.12581
复制
发表时间：
2018-06
影响因子：
5.4
通讯作者：
Wemmie JA
中科院分区：
文献类型：
--
作者：
Johnson CP;Christensen GE;Fiedorowicz JG;Mani M;Shaffer JJ Jr;Magnotta VA;Wemmie JA
定量T1ρ标测是一种对pH值和其他细胞和微结构因素敏感的磁共振成像技术，是识别双相情感障碍患者大脑改变的潜在有价值的工具。最近，这项技术确定了正常胸腺患者与健康对照组的小脑和大脑白色物质的差异，与这些区域的pH值降低一致，表明潜在的代谢异常。目前的研究建立在这一先前的工作，以调查大脑T1ρ的差异跨越正常的，抑郁的，躁狂的情绪状态的双相情感障碍。入组了40名双相I型障碍患者和29名年龄和性别平衡的健康对照者。双相情感障碍的参与者在一种或多种情绪状态下进行成像，分别产生27，12和13次正常情绪，抑郁和躁狂情绪状态的成像。采集所有参与者的三维全脑解剖图像和T1ρ图，从而能够对双相情感状态和健康对照组之间的T1ρ差异进行体素评估。与健康对照组相比，所有三个情绪状态组的小脑T1ρ松弛时间都增加了。此外，与对照组和正常胸腺组相比，抑郁组和躁狂组的基底神经节及其周围的T1ρ弛豫时间减少。这项研究暗示小脑和基底神经节在双相情感障碍的病理生理学及其情绪状态，其中的作用是相对未知的。这些发现激发了对异常的根本原因以及这些区域中代谢活动改变的潜在作用的进一步研究。
Quantitative T1ρ mapping is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients versus healthy controls consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study builds upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder. Forty participants with bipolar I disorder and 29 healthy control participants balanced for age and gender were enrolled. Participants with bipolar disorder were imaged in one or more mood states, yielding 27, 12, and 13 imaging sessions in euthymic, depressed, and manic mood states, respectively. Three-dimensional, whole-brain anatomical images and T1ρ maps were acquired for all participants, enabling voxel-wise evaluation of T1ρ differences between bipolar mood state and healthy control groups. All three mood state groups had increased T1ρ relaxation times in the cerebellum compared to the healthy control group. Additionally, the depressed and manic groups had reduced T1ρ relaxation times in and around the basal ganglia compared to the control and euthymic groups. This study implicates the cerebellum and basal ganglia in the pathophysiology of bipolar disorder and its mood states, the roles of which are relatively unexplored. These findings motivate further investigation of the underlying cause of the abnormalities, and the potential role of altered metabolic activity in these regions.
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影响因子：
6.8
作者：
Fatemi SH;Folsom TD;Rooney RJ;Thuras PD
通讯作者：
Thuras PD
影响因子：
3.3
作者：
Heng, Serene;Song, Allen W.;Sim, Kang
通讯作者：
Sim, Kang
影响因子：
3.7
作者：
Bolbecker AR;Hong SL;Kent JS;Klaunig MJ;O'Donnell BF;Hetrick WP
通讯作者：
Hetrick WP
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC
DOI：
10.1089/104454603322724931
发表时间：
2003-12-01
影响因子：
1.9
作者：
Cecil, KM;DelBello, MP;Strakowski, SM
通讯作者：
Strakowski, SM