Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.
Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.
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DOI：
10.1016/bs.pmbts.2020.02.004
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发表时间：
2020
影响因子：
--
通讯作者：
Kato I
中科院分区：
文献类型：
--
作者：
Silbergleit M;Vasquez AA;Miller CJ;Sun J;Kato I
越来越多的证据表明，常驻微生物的失衡（生态失调）会促进慢性炎症、免疫破坏和致癌代谢物的产生，从而导致肿瘤。然而，支持单个细菌种类与人类散发性癌症直接联系的证据仍然有限。本章重点介绍几种新兴的细菌毒素，这些毒素最近因其对人类口腔消化道癌症的潜在致癌特性而被表征，并且已记录了其在人体组织样本中的存在。这些包括由γ和ε变形菌门的不同成员产生的细胞致死膨胀毒素、来自哺乳动物口腔密螺旋体的牙菌素、多杀性巴氏杆菌毒素、两种梭杆菌毒素、FadA和Fap2、脆弱拟杆菌毒素、大肠杆菌素、细胞毒性坏死因子和来自大肠杆菌的α-溶血素和肠沙门氏菌AvrA。很明显，这些细菌毒素具有诱发多种癌症特征的生物活性。一些毒素直接与 DNA 或染色体相互作用，导致其断裂，导致突变和基因组不稳定，而另一些毒素则调节细胞增殖、复制和死亡，促进免疫逃避和肿瘤侵袭，撬动特定的癌基因和肿瘤抑制途径，例如 p53 和 β-catenin/Wnt。此外，大多数细菌毒素以复杂多样的机制控制促肿瘤炎症。尽管越来越多的实验室证据支持选定细菌毒素的致癌潜力，但我们需要更多来自人体研究的直接证据和来自生理相关实验动物模型的机制数据，这些数据可以反映体内慢性感染，并考虑微生物组之间细菌与细菌之间的相互作用。
Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This chapter focuses on several emerging bacterial toxins that have recently been characterized for their potential oncogenic properties toward human orodigestive cancer and the presence of which in human tissue samples has been documented. These include cytolethal distending toxins produced by various members of gamma and epsilon Proteobacteria, Dentilisin from mammalian oral Treponema, Pasteurella multocida toxin, two Fusobacterial toxins, FadA and Fap2, Bacteroides fragilis toxin, colibactin, cytotoxic necrotizing factors and α-hemolysin from Escherichia coli, and Salmonella enterica AvrA. It was clear that these bacterial toxins have biological activities to induce several hallmarks of cancer. Some toxins directly interact with DNA or chromosomes leading to their breakdowns, causing mutations and genome instability, and others modulate cell proliferation, replication and death and facilitate immune evasion and tumor invasion, prying specific oncogene and tumor suppressor pathways, such as p53 and β-catenin/Wnt. In addition, most bacterial toxins control tumor-promoting inflammation in complex and diverse mechanisms. Despite growing laboratory evidence to support oncogenic potential of selected bacterial toxins, we need more direct evidence from human studies and mechanistic data from physiologically relevant experimental animal models, which can reflect chronic infection in vivo, as well as take bacterial-bacterial interactions among microbiome into consideration.
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影响因子：
5.3
作者：
Blazkova H;Krejcikova K;Moudry P;Frisan T;Hodny Z;Bartek J
通讯作者：
Bartek J
靶细胞膜通透性介导的大肠杆菌血素蛋白的有效白细胞囊性作用。
影响因子：
15.3
作者：
Bhakdi, S;Greulich, S;Muhly, M;Eberspacher, B;Becker, H;Thiele, A;Hugo, F
通讯作者：
Hugo, F
影响因子：
5.7
作者：
Boesze-Battaglia K;Alexander D;Dlakić M;Shenker BJ
通讯作者：
Shenker BJ
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
3.4
作者：
Ateia IM;Sutthiboonyapan P;Kamarajan P;Jin T;Godovikova V;Kapila YL;Fenno JC
通讯作者：
Fenno JC