Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans.

Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans.
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中枢命令在人类剧烈间歇等长运动期间增加肌肉交感神经活动。

DOI:
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发表时间:
1995
影响因子:
20.1
通讯作者:
J. H. Mitchell
J. H. Mitchell
中科院分区:
医学1区
文献类型:
--
作者:
R. Victor;N. Secher;T. Lyson;J. H. Mitchell

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在持续等长运动中,中枢指令对肌肉交感神经活动(MSNA)的影响很小。为了确定中枢指令在间歇收缩时是否比持续收缩时对MSNA的影响更大,我们用微电极(腓神经)记录了9名有节奏呼吸的人类受试者在间歇等距握力时,在25%、50%和75%最大自愿收缩(MVC)时的MSNA。在部分神经肌肉阻断(静脉治疗)前后,对另外11名受试者进行了类似的实验,以隔离中枢指令的影响,同时最大限度地减少力输出,从而减少肌肉传入反馈。在此之前,25%和50% MVC的握感对MSNA没有影响,而75% MVC的握感使MSNA与握感同步,因此收缩期的MSNA比松弛期高5.7 +/- 1.3倍(平均+/- SEM, P < 0.001)。曲线化后,即使力输出下降到初始MVC的< 25%,MSNA的这种同步仍然没有衰减。从这些观察中,我们得出结论,在剧烈的间歇等长运动中,中枢指令引起运动活动和肌肉交感神经活动的同步。
During sustained isometric exercise, central command has very little effect on muscle sympathetic nerve activity (MSNA). To determine if central command has a greater effect on MSNA during intermittent than during sustained contractions, MSNA was recorded with microelectrodes (peroneal nerve) during intermittent isometric handgrip at 25%, 50%, and 75% maximum voluntary contraction (MVC) in 9 human subjects with paced breathing. Similar experiments were performed in 11 additional subjects before and after partial neuromuscular blockade (intravenous curare) to isolate the influence of central command while minimizing force output and thus muscle afferent feedback. Before curare, handgrip at 25% and 50% MVC had no effect on MSNA, whereas handgrip at 75% MVC synchronized the MSNA to the handgrip such that MSNA was 5.7 +/- 1.3 times higher (mean +/- SEM, P < .001) during the contraction periods than during the relaxation periods. After curare, this synchronization of MSNA persisted without attenuation, even though force output fell to < 25% of the initial MVC. From these observations, we conclude that central command causes synchronization of motor activity and muscle sympathetic activity during intense intermittent isometric exercise.
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