Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans.
Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans.
复制标题
中枢命令在人类剧烈间歇等长运动期间增加肌肉交感神经活动。
作者:
R. Victor;N. Secher;T. Lyson;J. H. Mitchell
During sustained isometric exercise, central command has very little effect on muscle sympathetic nerve activity (MSNA). To determine if central command has a greater effect on MSNA during intermittent than during sustained contractions, MSNA was recorded with microelectrodes (peroneal nerve) during intermittent isometric handgrip at 25%, 50%, and 75% maximum voluntary contraction (MVC) in 9 human subjects with paced breathing. Similar experiments were performed in 11 additional subjects before and after partial neuromuscular blockade (intravenous curare) to isolate the influence of central command while minimizing force output and thus muscle afferent feedback. Before curare, handgrip at 25% and 50% MVC had no effect on MSNA, whereas handgrip at 75% MVC synchronized the MSNA to the handgrip such that MSNA was 5.7 +/- 1.3 times higher (mean +/- SEM, P < .001) during the contraction periods than during the relaxation periods. After curare, this synchronization of MSNA persisted without attenuation, even though force output fell to < 25% of the initial MVC. From these observations, we conclude that central command causes synchronization of motor activity and muscle sympathetic activity during intense intermittent isometric exercise.
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DOI:
10.1113/jphysiol.1991.sp018480
发表时间:
1991
期刊:
The Journal of physiology
影响因子:
--
作者:
Matsukawa,K;Mitchell,JH;Wall,PT;Wilson,LB
通讯作者:
Wilson,LB
影响因子:
20.1
作者:
Hajduczok,G;Hade,JS;Mark,AL;Williams,JL;Felder,RB
通讯作者:
Felder,RB
DOI:
10.1152/ajpheart.1991.261.5.h1653
发表时间:
1991
期刊:
The American journal of physiology
影响因子:
--
作者:
Ettinger,S;Gray,K;Whisler,S;Sinoway,L
通讯作者:
Sinoway,L
DOI:
10.1152/jappl.1989.67.1.256
发表时间:
1989
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Rotto,DM;Stebbins,CL;Kaufman,MP
通讯作者:
Kaufman,MP
DOI:
10.1152/jappl.1985.58.3.936
发表时间:
1985
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
Rybicki,KJ;Waldrop,TG;Kaufman,MP
通讯作者:
Kaufman,MP