Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp.

Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp.
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DOI:
10.1021/np200886x
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发表时间:
2012-04-27
影响因子:
5.1
通讯作者:
Schmidt EW
Schmidt EW
中科院分区:
生物学2区
文献类型:
--
作者:
Lin Z;Flores M;Forteza I;Henriksen NM;Concepcion GP;Rosenberg G;Haygood MG;Olivera BM;Light AR;Cheatham TE 3rd;Schmidt EW

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Two new compounds, peptide-polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from Streptomyces sp. cultivated from the gastropod mollusk, Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey’s method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.
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影响因子: 5.1
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影响因子: 4.4
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发表时间: 2011-10-01
影响因子: 0.7
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