Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants.
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants.
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新冠肺炎恢复期患者中和抗体的时间成熟提高了对循环中的SARS-CoV-2变种的效力和广度。
DOI：
10.1016/j.immuni.2021.06.015
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发表时间：
2021-08-10
期刊：
影响因子：
32.4
通讯作者：
Takahashi Y
中科院分区：
文献类型：
--
作者：
Moriyama S;Adachi Y;Sato T;Tonouchi K;Sun L;Fukushi S;Yamada S;Kinoshita H;Nojima K;Kanno T;Tobiume M;Ishijima K;Kuroda Y;Park ES;Onodera T;Matsumura T;Takano T;Terahara K;Isogawa M;Nishiyama A;Kawana-Tachikawa A;Shinkai M;Tachikawa N;Nakamura S;Okai T;Okuma K;Matano T;Fujimoto T;Maeda K;Ohnishi M;Wakita T;Suzuki T;Takahashi Y
抗SARS-CoV-2抗体滴度随时间缓慢下降。在这里，我们研究了时间如何影响抗体效力。为了评估抗体成熟对针对原始SARS-CoV-2和新出现的关注变体（VOC）的持久中和活性的影响，我们分析了SARS-CoV-2感染后1-10个月的恢复期血浆中的受体结合结构域（RBD）特异性IgG抗体。总RBD IgG和中和抗体的纵向评价显示总抗体滴度下降，但每个抗体对原始SARS-CoV-2的中和效力提高，表明抗体应答成熟。用真实病毒进行的中和试验表明，能够中和原始SARS-CoV-2的早期抗体对B.1.351（501Y.V2）和P.1（501Y.V3）变体的反应性有限。恢复期晚期的抗体对VOC的中和效力增强，表明血浆中交叉中和抗体的持续存在。因此，对SARS-CoV-2的抗体应答的成熟增强了对循环变体的交叉中和能力，这表明抗体滴度下降可能并不表明保护作用下降。SARS-CoV-2变异体的抗原漂移允许COVID-19恢复期血浆中的中和抗体逃逸。Moriyama等人揭示了血清学免疫随时间的演变，通过亲和力成熟和持久激发抗病毒逃逸的IgG抗体来对抗SARS-CoV-2变体。
Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time affects antibody potency. To assess the impact of antibody maturation on durable neutralizing activity against original SARS-CoV-2 and emerging variants of concern (VOCs), we analyzed receptor binding domain (RBD)-specific IgG antibodies in convalescent plasma taken 1–10 months after SARS-CoV-2 infection. Longitudinal evaluation of total RBD IgG and neutralizing antibody revealed declining total antibody titers but improved neutralization potency per antibody to original SARS-CoV-2, indicative of antibody response maturation. Neutralization assays with authentic viruses revealed that early antibodies capable of neutralizing original SARS-CoV-2 had limited reactivity toward B.1.351 (501Y.V2) and P.1 (501Y.V3) variants. Antibodies from late convalescents exhibited increased neutralization potency to VOCs, suggesting persistence of cross-neutralizing antibodies in plasma. Thus, maturation of the antibody response to SARS-CoV-2 potentiates cross-neutralizing ability to circulating variants, suggesting that declining antibody titers may not be indicative of declining protection. Antigenic drifts in SARS-CoV-2 variants permit escape from neutralizing antibody in COVID-19 convalescent plasma. Moriyama et al. reveal the evolution of serological immunity with time that counters SARS-CoV-2 variants via affinity maturation and durable elicitation of IgG antibodies that are resistant to viral escape.
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影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
64.5
作者：
Hoffmann M;Arora P;Groß R;Seidel A;Hörnich BF;Hahn AS;Krüger N;Graichen L;Hofmann-Winkler H;Kempf A;Winkler MS;Schulz S;Jäck HM;Jahrsdörfer B;Schrezenmeier H;Müller M;Kleger A;Münch J;Pöhlmann S
通讯作者：
Pöhlmann S
影响因子：
30.3
作者：
McNamara, Hayley A.;Idris, Azza H.;Cockburn, Ian A.
通讯作者：
Cockburn, Ian A.
REGN-COV2抗体预防和治疗恒河猕猴和仓鼠中的SARS-COV-2感染。
DOI：
10.1126/science.abe2402
发表时间：
2020-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Baum A;Ajithdoss D;Copin R;Zhou A;Lanza K;Negron N;Ni M;Wei Y;Mohammadi K;Musser B;Atwal GS;Oyejide A;Goez-Gazi Y;Dutton J;Clemmons E;Staples HM;Bartley C;Klaffke B;Alfson K;Gazi M;Gonzalez O;Dick E Jr;Carrion R Jr;Pessaint L;Porto M;Cook A;Brown R;Ali V;Greenhouse J;Taylor T;Andersen H;Lewis MG;Stahl N;Murphy AJ;Yancopoulos GD;Kyratsous CA
通讯作者：
Kyratsous CA