A review on plant-derived natural products and their analogs with anti-tumor activity.
A review on plant-derived natural products and their analogs with anti-tumor activity.
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DOI：
10.4103/0253-7613.41038
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发表时间：
2008-03
影响因子：
2.4
通讯作者：
Shah DR
中科院分区：
文献类型：
--
作者：
Dholwani KK;Saluja AK;Gupta AR;Shah DR
传统药物，包括中草药配方，可以作为潜在新药的来源，初步研究集中在生物活性先导化合物的分离。用于抗癌活性的新型植物来源的天然产物及其类似物的开发详细描述了基于生物活性和作用导向的分离和表征机制以及基于合理药物设计的修饰来合成新衍生物的努力。此外，某些天然产物及其类似物的抗癌活性可以通过基于活性药效团模型合成新的衍生物来增强;耐药性和溶解性以及代谢限制可以通过适当的分子修饰来克服;并且新的生物学特性或作用机制可以通过组合其他官能团或分子来添加。然后，对体外人类细胞系组进行临床前筛选，并选择体内异种移植物测试，以确定最有前途的药物开发靶点。
Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their analogs for anticancer activity details efforts to synthesize new derivatives based on bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design - based modification. Also, the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance and solubility and metabolic limitations can be overcome by appropriate molecular modifications; and new biological properties or mechanisms of action can be added by combining other functional groups or molecules. Preclinical screening for in vitro human cell line panels and selected in vivo xenograft testing then identifies the most promising drug development targets.
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影响因子：
2.7
作者：
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通讯作者：
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影响因子：
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